炎症性肠病患者的妊娠相关问题

Pregnancy related problems in inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)好发于育龄期,女性患者在妊娠,分娩期可出现IBD活动或暴发加剧,使患者病情复杂化.IBD对妊娠结局的影响及育龄患者对药物或手术治疗干预的潜在需求,使得IBD患者妊娠问题的关注度逐年提高,患者也往往就生育,妊娠及母乳喂养问题进行咨询.本文就IBD患者的生育,妊娠及药物安全性进行探讨,建议临床医生指导患者消除恐惧心理,于静止期计划受孕,接受风险最小的个体化治疗,以获得良好的妊娠结局.

Inflammatory bowel disease（IBD） oftenaffects the young population and is prominent in the reproductive phase of their lives. Women with IBD often experience activation or flare during pregnancy and delivery, which complicates the patients＇ conditions. The important effects of IBD on pregnancy outcome and the potential need for medical or surgical interventions raise concerns about pregnancy issues. Questions about fertility, pregnancy and breast feeding are often asked by patients. The aim of this review is to discuss fertility and pregnancy in inflammatory bowel disease and the safety of drugs during pregnancy and lactation. We recommend that clinicians guide patients to eliminate fear, plan conception during stable remission, and accept the individual treatment with the minimum risk, in order to obtain a good pregnancy outcome.