摘要
内源性大麻素系统包括内源性大麻素物质、特异性大麻素受体1(cannabinoid receptor 1,CB1)和CB2.内源性大麻素系统在胃肠道疾病、肝脏疾病、胰腺疾病和肿瘤的发生发展过程中扮演了众多的生理效应和病理生理角色.本文就内源性大麻素系统、CB2与肠易激综合征、炎症性肠病、胰腺炎、肝脏疾病及消化系肿瘤的关系等作一综述.
The endocannabinoid system is made up of endocannabinoid, cannabinoid receptor type 1（CB1） and cannabinoid receptor type 2（CB2）. A multitude of physiological effects and putative pathophysiological roles have been proposed for the endogenous cannabinoid system in the gastrointestinal tract, liver, pancreas and tumors. This paper aims to review the endocannabinoid system and the relations of CB2 with irritable bowel syndrome, inflammatory bowel disease, pancreatitis, hepatic disease and digestive system tumors.
出处
《世界华人消化杂志》
CAS
2016年第3期400-407,共8页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
Nos.81170411
81570546
中国肝炎防治基金会王宝恩肝纤维化研究基金资助项目No.20080013
河北省自然科学基金资助项目
No.C2010000530
关键词
大麻素受体2
肠易激综合征
炎症性肠病
胰腺炎
肝脏疾病
消化系肿瘤
Cannabinoid receptor type 2
Irritable bowel syndrome
Inflammatory bowel disease
Pancreatitis
Hepatic disease
Digestive system tumor
