南京市梅山社区脂肪肝患病率及其危险因素回顾

Prevalence of and risk factors for fatty liver in Meishan community, Nanjing

目的:明确南京市梅山社区脂肪肝(fatty liver,FL)患病率、相关危险因素及其与代谢综合征其他组分的关系.方法:回顾性分析上海梅山医院体检中心25897例南京市梅山社区居民体检信息,根据性别、年龄、体质量指数(body mass index,BMI)、实验室检查及腹部超声检查结果,分析FL患病情况及其与代谢综合征其他组分的关系.结果:有完整病例资料的体检人群为19950例,检出FL患者共5948例,FL患病率为29.81%,其中男性4253例,男性患病率为30.24%,女性1695例,患病率为28.80%.FL的总患病率与年龄相关,各年龄组间差异有统计学意义(P=0.000<0.05);其中,女性FL与年龄相关,各年龄组间差异有统计学意义(P=0.022<0.05);男性各年龄组间差异无统计学意义(P=0.191>0.05).41-50岁组男性FL患病率高于女性,差异有统计学意义(P=0.031<0.05).Logistic回归分析显示BMI、收缩压、红细胞计数、血小板、血糖、谷丙转氨酶、甘油三酯、胆固醇是FL的危险因素.结论:南京市梅山社区FL患病率较高,与多重代谢紊乱因素有关,应改善不良生活习惯,对此类人员可采取积极干预措施.

AIM： To investigate the prevalence of and risk factors for fatty liver（FL） in Meishan community, Nanjing and its relationship with other components of the metabolic syndrome.METHODS： A retrospective study was performed to analyze the prevalence of and risk factors for FL in 25897 residents in Meishan community, Nanjing who participated in health examination at the Shanghai Meishan Hospital. Variables for the analysis included gender, age, body mass index（BMI）, laboratory tests and abdominal ultrasound examination. FL status and its relationship with other components of the metabolic syndrome were analyzed.RESULTS： The total prevalence rate of fatty liver was 29.81%, and the prevalence between age groups was statistically significant（P〈0.05）. The prevalence of fatty liver was significantly associated with age in the female group（P〈0.05）, but not in the male group（P〈0.05）. The prevalence of fatty liver in the 41-50 age groupwas significantly higher in males than in females（P〈0.05）. Logistic multivariate regression analysis indicated that the prevalence of FL was correlated to BMI, systolic blood pressure, red blood cell count, platelet, blood glucose, ALT, triglyceride, and cholesterol.CONCLUSION： The prevalence of FL in Meishan community, Nanjing is higher and related to multiple metabolic factors. Bad living habits need to be improved in patients with fatty liver and positive interventions should be taken to prevent and treat fatty liver.