米非司酮单用及与宫瘤消胶囊联用治疗子宫肌瘤的临床效果

Clinical efficacy of mifepristone alone and combined with gongliuxiao capsule in the treatment of uterine fibroids

目的探讨米非司酮单用及其与宫瘤消胶囊合用治疗子宫肌瘤的临床效果。方法选取2011年6月至2014年5月间收治的154例子宫肌瘤患者,按随机数字分组法分为治疗组和对照组。治疗组患者采用非司酮配合宫瘤消胶囊治疗,对照组患者采用米非司酮治疗,对比两组患者的治疗效果。结果治疗组患者治愈率(53.2%)和总有效率(92.2%)明显高于对照组患者(27.3%和(66.2%),差异均有统计学意义(均P<0.05)。两组患者治疗后,治疗组患者孕酮和雌二醇分别为(9.54±2.36)μg/L和(158.52±43.27)pmol/L,与对照组患者[分别为(16.42±3.21)μg/L和(220.43±45.36)pmol/L]对比,差异均有统计学意义(均P<0.05);两组患者经治疗后,治疗组患者子宫肌瘤体积和子宫体积分别为(33.25±12.42)m^3和(106.43±23.76)m^3,与对照组患者[分别为(45.74±15.52)m^3和(119.94±28.35)m^3]相比,差异均有统计学意义(P<0.05)。结论子宫肌瘤患者使用米非司酮配合宫瘤消胶囊治疗效果更显著,值得推广。

Objective To explore the clinical efficacy of mifepristone alone and combined with gongliuxiao capsule in the treatment of uterine fibroids. Methods The 154 cases of uterine fibroids patients were selected and divided into treatment group and control group. The treatment group was given mifepris- tone combined with gongliuxiao capsule treatment. The control group was given mifepristone treatment. The clinical efficacy of two groups were compared. Results Clinical curative effect of the treatment group was better than that in the control group （ P 〈 0.05 ）. The progesterone and estradiol levels of treatment group was decreased than that in control group （ P 〈 0. 05 ）. The myoma size and uterine volume of the treatment group was decreased than that in the control group （ P 〈 0. 05 ）. Conclusion The treatment effect of mifepristone combined with uterine fibroids in patients with uterine fibroids is more obvious, and it is worth pro- moting.