早期吞咽功能训练对鼻咽癌放疗患者功能恢复及生活质量的影响

Effect of early swallowing function training on functional recovery and quality of life for patients with nasopharyngeal carcinoma treated by radiotherapy

目的探讨早期吞咽功能训练对鼻咽癌放疗患者功能恢复及生活质量的影响。方法选取2010年1月至2015年7月间接受治疗的52例鼻咽癌放疗患者,根据随机数字法将其分为观察组和对照组,每组26例。观察组患者在常规治疗基础上,早期加用吞咽功能训练,对照组患者仅采用常规治疗。比较两组患者治疗前后吞咽功能的变化情况,以及放疗的临床疗效、吸入性肺炎发生率。根据生活质量测定量表(EORTC-QLQ-C30),评估和比较治疗前后患者生活质量各维度得分及总分变化情况。结果与对照组比较,观察组患者治疗后吞咽功能得到了明显改善,差异有统计学意义(P<0.05)。与对照组比较,观察组患者总有效率明显提高,吸入性肺炎发生率显著降低,差异有统计学意义(P<0.05)。与对照组比较,观察组患者治疗后生活质量各维度得分及总分均明显增高,差异有统计学意义(P<0.05)。结论早期吞咽功能训练有助于鼻咽癌放疗患者吞咽功能的恢复,明显提高放疗的临床疗效及生活质量。

Objective To explore the effect of early swallowing function training on functional re- covery and quality of life for patients with nasopharyngeal carcinoma treated by radiotherapy. Methods The 52 patients with nasopharyngeal carcinoma treated by radiotherapy in the department of Radiation Oncol- ogy in Huludao Central Hospital from January 2010 to July 2015 were randomized into the observation group （based on the routine treatment, addition to the early swallowing function training） and the control group （ routine treatment） according to the random number method, 26 cases in each group. The changes of swal- lowing function on pre-and post-treatment, the clinical efficacy of radiotherapy, the incidence of aspiration pneumonia, and the each dimension score and total scores of quality of life according to the European Organ- zation for Research and Treatment of Cancer quality of life-C30 （ EORTC QLQ-C30） in two groups were compared. Results Compared with the control group, the swallowing function was significantly improved on post-treatment in the observation group, with statistical difference （ P 〈 0. 05 ） ; Compared with the control group, the total effective rate was significantly increased and the incidence of aspiration pneumonia was ob- viously reduced in the observation group, with statistical difference （ P 〈 0. 05 ） ; Compared with the control group, the each dimension score and total scores of life quality were significantly increased on post-treatment in the observation group, with statistical difference （ P 〈 0.05 ）. Conclusion The early swallowing func- tion training can be helpful for the swallowing function recovery, and significantly increase the clinical effi-cacy of radiotherapy and patients＇ quality of life.