肺部给药吸收评价方法的研究进展

Research Progress in Absorption Evaluation Methods for Pulmonary Delivery

目的:综述评价药物肺部吸收转运常用的方法、技术手段。方法:通过查阅Pubmed、中国知网等数据库,系统地介绍评价药物肺部吸收的体外细胞模型、离体肺泡模型和体内动物模型,并对这些模型的优缺点及其应用进行综述。结果:根据研究目的及药物的性质选择合适的肺部吸收评价模型。结论:为肺部给药制剂的研究与开发提供理论基础和研究思路。

Objective： To review the drug absorption evaluation methods for pulmonary delivery. Methods： The drug absorption cell models, in vitro pulmonary membrane model and in vivo animal model were systematically summarized, and the advantages and disadvantages of those models and applications were reviewed by referring to the databases in CNKI and Pubmed. Results： The appropriate animal model and method for the study of pulmonary absorption should be chosen according to the experimental purpose and characteristics of drugs. Conclusion： The review provides the thoughts and theoretical basis for the research and development of pulmonary delivery.