驻呼和浩特市男性新兵高尿酸血症与痛风的流行病学调查

Epidemiological survey of hyperuricemia and gout in newly recruited young male soldiers in Hohhot City

目的调查驻呼和浩特市青年男性新兵高尿酸血症的患病情况,分析高尿酸血症的危险因素。方法采用整群抽样调查的方法,在内蒙古呼和浩特市选取1002名来自山东、吉林、内蒙古、甘肃、宁夏五省(自治区)新入伍的男性士兵为研究对象,利用新兵体检时机,采集外周静脉血2 ml,EDTA抗凝,4℃保存,检测血尿酸水平。设计高尿酸血症危险因素调查表进行问卷调查,调查结果应用SPSS13.0进行统计分析并进行Logistic回归分析。结果 (1)新兵高尿酸血症患病率为38.9%,高尿酸血症组血尿酸平均(474.18±87.40)μmol/L,正常血尿酸组血尿酸平均(355.85±49.07)μmol/L。痛风患病率为0。(2)高尿酸血症组体重指数、胆固醇、三酰甘油水平均明显高于正常血尿酸组(t分别为-6.254、-3.977、-4.025,P<0.01),差异有统计学意义。(3)与高尿酸血症有关的危险因素包括BMI≥25、饮用白酒和啤酒、饮酒量≥500 ml/周。结论在保障士兵饮食营养的同时,要减少脂肪、糖类及富含嘌呤等食物摄入,可降低高尿酸血症的发生率。

Objective To investigate the prevalence of hyperuricemia and gout among the newly recruited young male soldiers in Hohhot City in 2013, and to know how the young men contracted hyperuricemia. Methods A cluster sampling was conducted. 1002 newly recruited young soldiers were investigated in Hohhot, Inner Mongolia, who came from Shandong, Jilin, Inner Mongolia, Gansu, Ningxia, and the peripheral venous blood 2 ml samples were collected, EDTA anticoagulation, saved at 4℃, for serum uric acid （SUA） level detection when new recruit had physical examination test. The survey was conduct according to regressive analysis by SPSS13.0 software. Logistic regressive model of major pathogenic factors of hyperurieemia was constructed for the single factor of statis- tieaUy significant difference （ P 〈 0.05 ） and was analyzed latterly. Results （ 1 ） The prevalence of HUA was 38.9 % in young men. The mean of SUA was （474.18 ±87.40）umol/L in HUA group. The mean of SUA was （355.85±49.07）umol./L in normal uric acid group. The prevalence of gout was 0%. （2）The values of BMI, cholesterol, triglyceride in HUA group were higher significantly than those in the normal group （ t = - 6.254, - 3. 977, - 4.025, P 〈 0.01 ）. （3） The results of the logistic regression showed that BMI≥25, drinking white spirit and beer, capacity for liquor≥500 mL/week were the independent risk factors of hyperuricemia. Conchlsiolls We should reduce the food offered that is rich of fat, sugar and purine, when we should ensure nutrition of soldiers. Our purpose is reduce hyperuricemia to preserve and ensure fighting capacity of force.