食源性黄酮类化合物改善脂质代谢作用及其机制研究进展

Research Progress on the Hypolipidemic Effects of Flavonoids and the Related Molecular Mechanisms

黄酮类化合物是广泛存在于自然界中的一类多酚类化合物,已被研究证实具有十分广泛的生物活性。近年来,大量研究表明,黄酮类化合物对脂质代谢紊乱具有改善作用,对高脂血症及相关疾病亦有一定的预防和治疗作用。目前认为,黄酮类化合物改善脂质代谢的作用机制主要是通过调节机体对肠道中脂质的吸收和肝脏内脂质代谢过程,其中,固醇调节元件结合蛋白(sterol regulatory element binding proteins,SREBPs)、过氧化物酶体增殖物激活受体(peroxisome proliferators activated receptors,PPARs)以及肝脏X受体(liver X receptors,LXRs)这三类核转录因子在这一调控过程中发挥着至关重要的作用。该文综述了食源性黄酮类化合物改善脂质代谢作用及其作用机制,并对其中存在的相关问题进行了初步分析和展望。

Flavonoids are a large group of polyphenolic compounds extensively existing in plants with powerful biological properties. Until recently, various studies have shown the beneficial effects of flavonoids in lipid metabolic disorders, suggesting a preventive and therapeutic effect on the diseases associated with hyperlipidemia. It has been found that the mechanism of hypolipidemic effects by flavonoids may be mainly related with regulation of intestinal lipid absorption and lipid metabolism in the liver. Moreover, sterol regulatory element binding proteins （SREBPs） play a key role in the regulation processes as well as peroxisome proliferators activated receptors （PPARs） and liver X receptors （LXRs）. This review focuses on the hypolipidemic effects of dietary flavonoids and their basic biochemical and molecular mechanisms. In addition, the potential problems in this research area are also discussed.