检测同型半胱氨酸在不同分期结肠癌患者血浆中的变化

Changes of homocysteine in the plasma of colon cancer patients in different stages

目的检测不同分期结肠癌患者血浆中同型半胱氨酸(homocysteine,Hcy)水平,分析肿瘤分期与Hcy的关系,并初步探讨其在结肠癌患者中的临床意义。方法选取2013年9月-2014年10月就诊于内蒙古医科大学附属赤峰医院经病理学(结肠镜)确诊的未行任何治疗的结肠癌患者为试验组,选取同期健康体检者为对照组。电化学发光方法检测试验组及对照组血浆Hcy水平。结果经确诊的80例结肠癌患者中,Hcy升高者26例,平均值为(14.62±3.24)μmol/ml。对照组80名健康人中,升高者2名,平均值为(10.25±2.01)μmol/ml。两者相比较,差异有显著性统计学意义(P<0.01)。在Hcy升高的结肠癌患者中,随着肿瘤分期的升高,Hcy随之升高,差异有统计学意义(P<0.01)。结论对于确诊结肠癌的患者,Hcy有望成为结肠癌的标志物,能够辅助诊断、评价疗效、监测肿瘤复发。

Objective To detect the changes of homocysteine （Hcy） in the plasma of colon cancer patients in different stages, to analyze the relationship between tumor stages and Hcy, and to explore its clinical significance. Methods Colon cancer patients diagnosed by pathology （endoscopy） without any treatment in Chifeng Hospital of Affiliated Inner Mongolia Medical University from Jun. 2013 to Oct. 2014 were collected as experiment group, healthy people as controls group. Hcy levels in plasma of the experiment group and the control group were collected by electrochemilumi- nescence methods. Results There were 26 cases with increased Hcy in 80 cases of colon cancer, average level of Hcy was （ 14.62 ± 3.24） μmol/ml. There were 2 cases with increased Hcy in 80 healthy people, average level of Hcy was （10.25 ±2.01 ） μmol/ml （P 〈0.01 ）. In the colon cancer patients that Hcy elevated, with increasing the staging of tumor, the level of Hcy in plasma was increasing, there was statistically significant （P 〈 0.01 ）. Conclusion For patients with colon cancer, Hcy is expected as colon cancer markers which could auxiliary diagnose, evaluate curative effect and monitor tumor recurrence.