膳食叶酸、维生素B_6、维生素B_(12)摄入量与原发性肝癌关系的病例对照研究

Dietary intake of folate,vitamin B_6,vitamin B_(12) and risk of primary liver cancer in a case-control study

目的通过评估研究对象平均每日叶酸、维生素B_6、维生素B_（12）的摄入量,分析叶酸、维生素B_6及维生素B_（12）摄入量与原发性肝癌的关系,并探讨饮酒是否影响叶酸、维生素B_6及维生素B_（12）摄入量与原发性肝癌的关系。方法采用1∶1匹配病例对照研究方法,运用半定量79条目食物频率问卷对411例原发性肝癌患者及411例对照进行面对面问卷调查,收集研究对象近1年的膳食情况,运用条件Logistic回归模型分析叶酸、维生素B_6、维生素B_（12）摄入量与原发性肝癌的关系。结果校正可能的混杂因素后,发现高叶酸摄入量能显著增加原发性肝癌的发病风险,叶酸摄入量最高组（T3）发生原发性肝癌的风险是最低组（T1）的1.97倍（95%CI：1.13~3.46,P=0.011）。而维生素B_6与维生素B_（12）摄入量对原发性肝癌的影响无统计学意义（P〉0.05）。在不饮酒人群中,高叶酸摄入量能显著增加原发性肝癌的发病风险（OR=2.38,95%CI：1.45~3.91;P〈0.001）;而在饮酒人群中,叶酸摄入量对原发性肝癌发病风险的影响无统计学意义（P〉0.05）。结论高叶酸摄入量可能增加原发性肝癌的发病风险,尤其在非饮酒人群中。

Objective In our study, we evaluated the average daily dietary intake of folate, vitamin B6 and vitamin B12, and investigated the association between dietary intake of related B vitamins and risk of primary liver cancer （PLC） and evaluated whether these correlations were modified by alcohol drinking. Methods A 1 ： 1 case-control study was conducted with 411 PLC cases and 411 controls. Face-to-face interviews were carried to assess habitual dietary intakes using a 79-item food frequency questionnaire （FFQ）. Conditional logistic regressions were used to analyze the association between dietary intake of related B vitamins and risk of PLC. Results With adjustments＇ made for several possible confounders, significantly positive association was observed between folate intake and PLC risk, the OR of the highest tertile relative to the lowest tertile of folate intake was 1.97 （95% CI： 1.13-3.46, P=0.011 ）. No association was found for vitamin B6 or vitamin B12 （P〉0.05）. Among non-drinkers, folate intake was positively associated with PLC risk （OR=2.38, 95%（2/： 1.45-3.91 ; P〈0.001）. However, no significant association between folate intake and risk of PLC was observed among drinkers. Conclusion The present study suggests that higher consumption of folate possibly increased the risk of PLC, especially for non-drinkers.