不同年龄类风湿关节炎患者的临床特征

Clinical analysis of different ages patients with rheumatoid arthritis

目的探讨类风湿性关节炎（RA）中青年组与老年组的临床特征。方法对69例17~60岁中青年与51例60岁以上的老年患者的临床资料进行比对分析。结果老年组以心血管病变、胃肠受累、骨关节炎、肺间质病变多见,与中青年组比较差异有统计学意义（P〈0.05）;与中青年组比较,老年组中血清C反应蛋白（CRP）显著升高[（33.1±21.2）mg/L vs（61.0±20.3）mg/L],而类风湿因子（RF）（75.3%vs 37.3%）与抗环瓜氨酸肽抗体（抗CCP抗体）阳性率（59.4%vs 35.2%）降低,差异均有统计学意义（P〈0.05）。结论老年组的关节病变与合并疾病所占比例明显高于中青组,且老年组RA并发症类型、发病机制与中青年显著不同。

Objective To explore the clinical characteristics of rheumatoid arthritis （RA） in different age group. Methods 69 cases of RA patients in the young group with ages between 17 to 60 years old, and 51 cases in the older group with ages older than 60 were recruited for the study. Clinical data of the two groups were compared and analyzed. Results Cardiovascular and gastrointestinal disease, osteoarthritis, and interstitial lung disease were more common in the older group, and the different was statistically significant （P〈0.05）; the serum C-reactive protein （CRP） level of the older group was significantly higher; rheumatoid factor （RF） and anti-cyclic citrullinated peptide antibody positive rate were significantly lower in the older group（P〈0.05）. Conclusion The proportion of joint disease and comorbidities in the older group was significantly larger than the younger group and rheumatoid arthritis complication types and pathogenesis was different with the younger group.