炎症反应在阿尔茨海默病发病机制中的研究进展

Role and research progress of inflammation in the mechanism of Alzheimer′s disease

阿尔茨海默病(AD)是最为常见的老年神经记忆功能退行性疾病之一,主要的病理临床特征为Aβ蓄积形成的老年斑(SP)和高度磷酸化tau蛋白导致的神经纤维缠结(NFTs)。此外,胶质细胞过度激活释放的各种炎症因子和神经毒素,引发的一系列炎症反应也被认为参与了SP和NFTs的形成,是AD的另一主要病理学特征。本文就炎症反应在AD发病机制中的作用及最新研究进展展开综述。

Alzheimer＇s disease is one of the most common neurodegenerative disorders in the elderly. Inflammation of gliacytes is considered one of the pathological hallmarks in AD, except of the formation senile plaques （SP） composed of deposition of 13-amyloid and neurofibrillary tangles （neurofibrilary tangles tangles, NFTs） caused by hyperphosphorylated tau protein. In this paper, we reviewed the generation of inflammation, and its role in the progress and mechanism of AD.