Brugada综合征研究进展

Research progress of Brugada syndrome

Brugada综合征是一种有遗传倾向的以恶性心律失常为主要表现的综合征,由于编码心脏Na离子通道的基因(SCN5A)突变而发病。1992年Brugada兄弟描述其特征性心电图表现,之后发现该疾病又有夜间猝死这一凶险的预后,因此一直是心血管疾病基础和临床研究领域内的一大前沿和焦点。本文就BS的流行病学、遗传基础及细胞学机制和心电图特征等方面最新研究进展作一综述。

Bmgada syndrome is a syndrome characterized by a genetic predisposition to malignant arrhythmia, which is due to mutations in the gene （SCN5A） of the cardiac Na ion channel. 1992 Brugada brothers describe the characteristics of electrocardiogram （ECG） and found that the disease has a danger of sudden death at night. So it has been a major focus of frontier and basic clinical research within the field of cardiovascular disease. This paper reviewed the latest research progress of the epidemiology, genetic basis, and the characteristics of ECG of Brugada syndrome.