中药保留灌肠治疗放射性直肠炎疗效的系统评价

Systematic evaluation on curative effect of traditional Chinese medicine retention enema for patients with factitial proctitis

[目的]系统评价中药保留灌肠治疗放射性直肠炎的疗效。[方法]计算机检索The Cochrane Library,PubMed,EMbase,EBSCO,ISI,CNKI,VIP,WanFang Data和CBM数据库中关于中药保留灌肠治疗放射性直肠炎的随机对照试验,检索时限均从建库至2014年5月,由两名研究者按照纳入排除标准独立进行文献筛选、资料提取、质量评价并交叉核对后,采用RevMan5.3软件进行Meta分析。[结果]共纳入14个随机对照试验(RCT),进行Meta分析的有10项RCT,共702例病人。Meta分析显示,与对照组相比,中药保留灌肠治疗放射性直肠炎的总有效率较高[RR=4.83,95%CI为(2.98,7.84),P<0.000 01];4项研究结果均显示中药保留灌肠改善临床症状优于对照组。[结论]对放射性直肠炎病人实施中药保留灌肠干预能提高治疗的总有效率,减轻临床症状。

Objective：To systematically evaluate the curative effect of retention enema of Chinese traditional medicine for patients with factitial proctitis.Methods：Randomized controlled trial about traditional Chinese medicine retention enema in the treatment of radiation proctitis were searched in the Cochrane Library, PubMed,EMBASE,EBSCO,ISI,CNKI,VIP,Wanfang Data and CBM databases.The retrieval time was from inception to May 2014,and literature screening,data extraction,quality evaluation and cross check were conduc-ted by two researchers independently in accordance with the inclusion and exclusion standard,and then Meta a-nalysis was carried out by using RevMan5.3 software.Results：A total of 14 randomized controlled trials（RCT） were included,and Meta analysis included 10 RCTs totally 702 patients.Meta analysis showed that the total effi-ciency of traditional Chinese medicine retention enema was higher for patients with radiation proctitis compared with that in control group,RR=4.83,95%CI（2.98,7.84）,P〈0.000 01;four study results showed that tradi-tional Chinese medicine retention enema improving the clinical symptoms was better than that in control group. Conclusion：Implementation traditional Chinese medicine of retention enema intervention in patients with radia-tion proctitis could improve the total efficiency of the treatment and relieve the clinical symptoms.