1,2-二亚油酸-3-二甲基氨丙烷类阳离子脂质纳米粒的研究进展

Research progress of 1,2-dilinoleyloxy-3-dimethylaminopropane-based cationic lipid nanoparticle

阳离子脂质纳米粒具有安全、高效和粒径可控的优点,现已成为核酸药物体内外递送载体的研究热点。该纳米粒的重要组分为阳离子脂质,其中以1,2-二亚油酸-3-二甲基氨丙烷(DLin DMA)及其衍生物为代表的新型材料,因递药效能高,生物相容性好而受到广泛关注。本文介绍了此类阳离子脂质的结构及特点,并对Dlin DMA纳米粒的构造、药物递送机制和临床应用进行了综述。

Cationic lipid nanoparticles possessing favorable biocompatibility and controllable particle size have attracted increasing attention in the field of non-viral vectors for delivering nucleic acids in vitro and in vivo. 1,2- Dilinoleyloxy-3-dimethylaminopropane（DLinDMA） and its derivatives, one kind of most important cationic lipid materials, have been widely studied as the main composition of cationic lipid nanoparticles. This paper sunamari- zes the structure, characteristics and clinical application of DLinDMA nanoparticles.