不育方剂的组方规律数据挖掘分析

Analysis on Composition Principles of Prescriptions for Infertility by Data Mining Method

目的:挖掘《中医方剂大辞典》中治疗不育方剂的组方用药规律。方法:整理、筛选《中医方剂大辞典》中收载的治疗不育方剂,输入中医传承辅助系统,基于数据挖掘方法挖掘组方规律,采用Apriori算法、复杂系统熵聚类等研究方法,确定处方药物的使用频次及药物间的关联规则等。结果:筛选出符合标准的方剂136首,总结归纳出治疗不育高频中药有:"枸杞子","熟地黄","当归","菟丝子","茯苓","山药"等,高频次药物组合包括"枸杞子,菟丝子","枸杞子,熟地黄","当归,熟地黄","五味子,菟丝子";置信度较高的关联规则包括:"山药,熟地黄->山茱萸","山药,菟丝子->枸杞子","牛膝->枸杞子";在确立的组方用药模式及规则基础上,最终获得新处方4首,包括"熟地黄,麦冬,天冬,远志,巴戟天,杜仲","熟地黄,麦冬,人参,大青盐,花椒,蜂蜜","韭菜子,龙骨,覆盆子,菟丝子,山茱萸,五味子,山药","远志,巴戟天,肉苁蓉,麦冬,黄柏,地黄,天冬"。结论:治疗不育方剂的用药,性味多以甘温药物为主,归经主入肾经、肝经、心经等;功效以补益作用居多,包括补阴药、补阳药和补气类中药,且多数具有肝肾同补作用。治疗不育的新方,其组方规律以补益为主,呈"填精壮阳,交通心肾"等特点,为临床提供了新的组方思路与线索。

Objective： To summarize the composition principles of prescriptions for infertility from Prescription Dictionary of Traditional Chinese Medicine. Method： Prescriptions used for infertility were selected from the Prescription Dictionary of Traditional Chinese Medicine, and input into the Traditional Chinese Medicine Inheritance Support System （V2.5）. Then by using data mining methods, composition principles of the prescriptions were analyzed ; and the methods of association rules with apriori algorithm and complex system entropy cluster were used to determine the usage frequency of herbs and association rules between the herbs. Result： The 136 eligible prescriptions were selected and the herbs with high usage frequency in the prescriptions for infertility included ＇ Lycii Fructus＇ , ＇ Rehmanniae Radix Preparata＇ , ＇ Angelicae Radix Sinensis＇ , ＇ Semen Cuscutae＇ , ＇ Poria＇, and ＇ Dioscoreae Rhizoma＇ The herb combinations with high usage frequency were ＇ Lycii Fructus, Cuscutae Semen＇ , ＇ Lycii Fructus, Rehmanniae Radix Preparata＇ , ＇ Angelicae Radix Sinensis, Rehmanniae Radix Preparata＇ , and ＇ Schisandrae Chinensis Fructus, Cuscutae Semen ＇ The association rules with high confidence coefficient included ＇Dioscoreae Rhizoma, Rehmanniae Radix Preparata-〉 Corni Fructus＇, ＇ Dioscoreae Rhizoma, Cuscutae Semen- 〉 Lycii Fructus＇ , and ＇ Achyranthis Radix Bidentatae- 〉 Lycii Fructus＇. Four new prescriptions were obtained based on the composition principles and rules, including ＇ Rehmanniae Radix Preparata, Ophiopogonis Radix, Asparagi Radix, Polygalae Radix, Morindae Officinalis Radix, Eucommiae Cortex＇ , ＇Rehmanniae Radix Preparata, Ophiopogonis Radix, Ginseng Radix et Rhizoma, Halitum, Zanthoxyli Pericarpium, Cera Flava＇ , ＇ Allii Tuberosi Semen, Os Draconis, Rubi Fructus, Cuscutae Semen, Corni Fructus, Schisandrae Chinensis Fructus, Dioscoreae Rhizoma＇ , ＇ Polygalae Radix, Morindae Officinalis Radix, Cistanches Herba, Ophiopogonis Radix, Phellodendri Chinensis Cortex, Rehmanniae Radix, Ophiopogonis Radix＇ Conclusion： The common used herbs for infertility are sweet and warm-natured and go into the channels of kidney, liver and heart, and the Chinese medicine applied in the prescriptions for infertility mostly have the tonifying effects, invigorating Yin, Yang and Qi, and most of the prescripti＇ons could tonify liver and kidney simultaneously. The new prescriptions for infertility are mainly of tonifying effects, with the characteristics of ＇ invigorating the kidney and strengthening Yang＇ and ＇restoring normal coordination between heart and kidney＇. This pattern will provide new prescription ideas and thoughts for clinical practice.