心气虚动物模型的建立及其评价研究进展

Progress in Establishment and Evaluation of Animal Models of Heart Qi Deficiency

心血管疾病是目前导致人类死亡与残疾的三大主要疾病之首,严重危害人类健康和生活质量。心气虚证是心血管疾病中最为常见的中医证型,因此心气虚动物模型的研究对心血管疾病的防治具有重要的指导意义和应用价值。动物模型是实验研究的基础,建立动物模型的方法应与疾病的实际发展过程相符合,动物模型的评价指标也应尽量与临床指标相对应。文章综述了心气虚动物模型制备和评价的研究现状,提出了当前心气虚动物模型研制中存在的问题,为该动物模型的建立与研究提供参考。

Cardiovascular disease is the first cause of death and disability among three major diseases, seriously impairing human health and life quality. Heart Qi deficiency syndrome is the most common traditional Chinese medicine syndrome of cardiovascular disease, so the study of animal models of heart Qi deficiency has important guiding effect and great application value for the prevention and treatment of cardiovascular disease. The experimental study is based on animal models, so the methods to establish animal models shall be in line with the actual development process of disease, and the evaluation indicators of animal models shall also correspond to the clinical indicators to the greatest extent. This article introduces the research status of the establishment and evaluation of animal models of heart Qi deficiency, proposes the problems existing in the establishment of heart Qi deficiency-animal models, and provides reference for the establishment and study of this animal model.