马来酸氟伏沙明治疗老年抑郁40例疗效与安全性研究

Efficacy and Safety of Maleic Acid Fluvoxamine for Treating Elderly Depression in 40 Cases

目的观察马来酸氟伏沙明治疗老年抑郁的临床疗效与安全性。方法选取收治的老年抑郁症患者80例,随机分为观察组和对照组,各40例。观察组给予马来酸氟伏沙明（50~150 mg）口服治疗,每日1次;对照组给予氟西汀（20~40 mg）口服治疗,每日1次;两组均以8周为1个疗程。治疗前和治疗后第1,2,4,8周末采用17项汉密尔顿抑郁量表（HAMD）评定两种药物临床疗效,采用副反应量表（TESS）评价两种药物治疗的安全性。结果两组患者治疗8周后,观察组患者治疗总有效率为77.50%,与对照组的72.50%相当,差异无统计学意义（P〉0.05）;观察组治疗第1周末和第2周末的HAMD评分结果显著低于对照组（P〈0.01）,第1周末HAMD焦虑因子得分显著低于对照组（P〈0.05）;两组治疗后的TESS评分均无明显差异（P〉0.05）;观察组患者恶心发生率为12.50%,明显低于对照组的45.00%（P〈0.01）。结论马来酸氟伏沙明和氟西汀在老年抑郁症患者治疗中均有效,两种药物疗效相当,但马来酸氟伏沙明具有起效更快、不良反应发生率更低的优点,是安全有效的治疗药物,值得临床推广。

Objective To observe the clinical efficacy and safety of maleic acid fluvoxamine in treating elderly depression. Methods 80 cases of elderly patients with depression were randomly divided into the observation group and the control group, 40 cases in each group. The observation group received maleic acid fluvoxamine （50- 150 mg）, oral treatment once daily; the control group received flu- oxetine （20-40 rag） oral treatment once daily. 8 weeks was 1 course of a treatment. Before and after 1, 2, 4, 8 weekend of treatment, the 17 Hamilton Depression Scale （HAMD） was used to assess the clinical efficacy of the two drugs, and the use of side effects scale （TESS） was used to evaluate the safety of the two drugs. Results After 8 weeks of treatment, the total effective rate of the observation group was 77.50%,which had no statistically significant difference with 72.50% of the control group（P 〉 0.05）; the HAMD scores of the observation group in the first and the second week were significantly lower than the control group（ P 〈 0. 01）, the HAMD anxiety factor score in the first weekend was significantly lower than the control group（ P 〈 0. 05）; the TESS scores of the two groups after treatment were not significantly different（ P 〉 0.05）; the incidence of nausea in the observation group was 12.50%, which was signifi- cantly lower than 45.00% in the control group（ P 〈 0. 01 ）. Conclusion Maleic acid fluvoxamine and fluoxetine are effective in the treatment of elderly patients with depression, and the efficacy of the two drugs are equivalent. But maleic acid fluvoxamine has a faster onset, lower incidence of adverse reactions advantage： it is a safe and effective treatment, which is worthy of Promotion.