芍药甘草汤的镇痛抗炎作用研究

Analgesic and Anti-Inflammatory Efficacy of Paeornia and Glycyrrhiza Dicoction

目的研究芍药甘草汤的镇痛和抗炎作用,探讨药物间的相互作用。方法采用二甲苯致小鼠耳肿胀,蛋清致小鼠足肿、热板法、醋酸扭体法。结果芍药甘草汤显著延长小鼠热板法的痛阈值,降低醋酸所致小鼠扭体反应次数;抑制二甲苯所致小鼠炎症,但对蛋清诱导的炎症无效;芍药的作用类似于芍药甘草汤,但药效较弱;甘草无明显的抗炎镇痛抗炎作用。结论甘草芍药汤有明显抗炎、镇痛作用,其与甘草提高芍药的作用有关。

Objective To study the analgesic and anti- inflammation efficacy of the Paeornia and Glycyrrhiza Dicoction and to investi- gate the interaction between drugs. Methods Hot plate and writhing test were applied to observe analgesic effect in mice; the models of the ear swilling and paw edema of mice were adopted to assay anti- inflammation. Results The Paeornia and Glycyrrhiza Dicoction ob- viously prolonged pain latency on hot plate, decreased the writhing response and inhibited the paw edema of mice, but no effect on the pedal swelling rate induced by egg white. Paeornia showed similar to effect of Paeornia and Glycyrrhiza Dicoction, but its efficacy was weak. Glycyrrhiza had not the analgesic effect, but it could enhance the analgesic effect of paeornia. Conclusion Paeornia and Gly- cyrrhiza Dicoction has anti- inflammation and analgesic efficacy Glycyrrhiza elevates the analgesic effect of paeornia.