摘要
目的了解美托洛尔致不良反应的情况,为临床安全、合理用药提供参考。方法检索2000年至2015年国内医药期刊中有关美托洛尔致不良反应的个案报道16例,采用文献计量学方法进行总结性分析。结果美托洛尔致不良反应包括心动过缓、心房颤动、关节疼痛各2例;室上性逸搏心率,窦性停搏,室上心动过速,Q-T间期延长,颜面及双下肢浮肿,阵发性头痛、胸闷加重,干咳,脱发、白发,视物模糊及腹部肌肉酸痛各1例。结论临床应重视美托洛尔的不良反应,加强临床用药监测。
Objective To promote clinical rational drug safety by analyzing the adverse drug reactions caused by metoprolol. Methods A total of 16 metoprolol- induced ADR cases collected from domestic articles in 2000- 2015 were analyzed statistically by bibliometric methods. Results The adverse reactions induced by metoprolol included bradycardia, atrial fibrillation, and joint pain in 2 cases re- spectively; supraventricular escape heart rate, sinus arrest, supraventricular tachycardia, QT prolongation, face and lower limbs edema, parox- ysmal headache, chest tightness aggravated, dry cough, hair loss, white hair, blurred vision and abdominal muscle pain each in 1 case re- spectively. Conclusion Physicians should pay more attention to patient safety after taking metoprolol, and should strengthen the mon- itoring of clinical medicine.
出处
《中国药业》
CAS
2016年第3期54-56,共3页
China Pharmaceuticals
关键词
美托洛尔
文献分析
药品不良反应
metoprolol
literature analysis
adverse drug reaction
