前列地尔联合尼莫地平防治动脉瘤性蛛网膜下腔出血致脑血管痉挛28例

Prostaglandin E1 Combined with Nimodipine for Preventing Aneurysmal Subarachnoid Hemorrhage Caused by Cerebral Vasospasm in 28 Cases

目的观察前列地尔联合尼莫地平对动脉瘤性蛛网膜下腔出血所致脑血管痉挛的疗效。方法将56例患者随机分为观察组(前列地尔联合尼莫地平)和对照组(尼莫地平),记录术后平均血压水平,监测7,14 d大脑中相关指标,随访6个月,应用Rankin评分评价预后。结果术后平均收缩压水平,对照组明显低于观察组(P<0.05);术后14 d显示观察组平均动脉血流速度(MCAVm)及Lindigarrd指数明显低于对照组(P<0.05);术后7 d MCAVm及Lindigarrd指数差异无统计学意义(P>0.05),两组患者预后Rankin评分比较,差异有统计学意义(P<0.05)。结论联合用药可更好地防治脑血管痉挛的发生,预防术后严重并发症的发生,改善患者预后。

Objective To observe the efficacy of prostaglandin E1 combined with nimodipine for preventing aneurysmal subarachnoid hemorrhage caused by cerebral vasospasm. Methods 56 patients were randomly divided into observation group（Prostaglandin E1 com- bined with nimodipine） and control group （nimodipine）. The average blood pressure levels, cerebral artery blood flow velocity and other indicators at postoperative 7 and 14 d were recorded. Those cases were followed up for 6 months by using Rankin score evaluation of prognosis. Results Postoperative average systolic blood pressure levels of the control group was significantly lower than the observation group（ P 〈 O. 05）; MCAVm and Lindigarrd indexes of the observation group was obviously lower than the control group at postoperative 14 d（P 〈 0.05）; at postoperative 7 d, there was no statistically significant difference in the Lindigarrd indexes of the two groups（P 〉 0.05）; the Rankin scores of the two groups had statistically significant differences（ P 〈 O. 05）. Conclusion The drug combination can better prevent cerebral vasospasm, as well as the occurrence of oostooerative complications and improve the oroznosis of natients.