DPC4和Smurf2在子宫内膜腺癌中的表达及临床意义

Expression and Clinical Significance of DPC4 and Smurf2 in Endometrial Carcinoma

目的检测胰腺癌缺失基因(DPC4)及Smad泛素化调节因子2(Smurf2)在增殖期子宫内膜、子宫内膜不典型增生及子宫内膜腺癌组织中的表达,探讨两者与子宫内膜腺癌发生发展的关系。方法采用免疫组化SP法检测DPC4和Smurf2在上述3种组织中的表达情况,并结合年龄、病理分期、组织学分级、肌层浸润深度及淋巴结转移等临床特征进行相关性分析。结果与增殖期子宫内膜表达相比在子宫内膜腺癌中,DPC4呈低表达,而Smurf2呈高表达(均P<0.05),两者呈负相关(r=-0.525,P<0.05),两因子在子宫内膜腺癌中的表达均与其病理分级和临床分期相关(均P<0.05),而与淋巴结转移、癌肿浸润肌层深度及年龄无关(均P>0.05)。结论DPC4和Smurf2均与子宫内膜腺癌的发生发展相关,两者均与其病理分级和临床分期有关,而与淋巴结转移及癌肿浸润肌层深度无关,可作为肿瘤恶性程度及预后指标。

Objective To detect the expression of deleted in pancreatic cancer locus （DPC4） and Smad ubiquitin regulatory factor 2 （Smurf2） in the normal endometrium, atypical hyperplasia and endometrial adenocarcinoma, and explore the relationship between the expression and the development of endometrial adenoearcinoma. Methods The immunohistochemistry of streptavidin-peroxidase method was used to detect the expression of DPC4 and Smurf2 in the endometrial tissue. The relationship were analyzed between the expression and clinical characteristics of age, pathological stage, differentiation degree, tumor invasive depth and lymph node metastasis. Results DPC4 was lowly expressed in endometrial adenocarcinoma, however Smurf2 was showed high expression （ P 〈 0.05 ）. The expression of the two facters were a negative correlation in endometfial adenocarcinoma （r = - 0. 525, P 〈 0. 05 ）. They were correlation with the pathological grade and clinical stage of endometrial adenocareinoma （P 〈 0.05）, but not a relationship between the expression and lymph node metastasis, tumor invasive depth and age （P 〉 0.05 ）. Conclusion DPC4 and Smurf2 were correlation with the development of endometrial adenocarcinoma. The expression of two factors were correlation with the pathological grade and clinical stage, but not with lymph node metastasis, tumor invasive depth. It can be used as an indicator malignant degree and prognosis of endometrial adenocarcinoma.