老年冠心病心力衰竭患者血清高敏C反应蛋白、N末端钠尿肽前体与左心室射血分数的相关性研究

Correlation study of serum hs-CRP and NT-proBNP with LVEF in elderly patients with coronary heart disease

目的探讨老年冠心病心力衰竭患者血清高敏C反应蛋白(hs-CRP)、N-末端脑钠肽前体(NT-proBNP)与左心室射血分数(LVEF)的相关性。方法选择76例老年冠心病心力衰竭患者纳入观察组,老年健康体检者25例纳入对照组,比较不同研究对象间血清hs-CRP、NT-proBNP与LVEF水平。结果观察组血清hs-CRP、NT-proBNP及LVEF水平均明显高于对照组,差异具有统计学意义(P<0.05);观察组心功能不同分级患者血清hs-CRP、NTproBNP浓度随着NYHA心功能分级的升高而增高,LVEF则逐级下降,不同分级间两两比较,差异均有统计学意义(P<0.05);观察组患者血清hs-CRP、NT-proBNP与LVEF均呈负相关(P<0.05)。结论血清hs-CRP、NT-proBNP随着老年冠心病心力衰竭患者心功能分级的递增而逐渐升高,且与LVEF均呈负相关。

Objective To investigate the correlation of serum hs-CRP and NT-proBNP with LVEF in elderly patients with coronary heart disease. Methods 76 elderly patients with coronary heart disease were included into the observation group,25 cases of elderly healthy subjects included into the control group,the serum hs-CRP, NT-proBNP levels and LVEF were compared. Results The serum hs-CRP,NT-proBNP and LVEF in the observation group were significantly higher than the control group, the difference was of statistically significant （P〈0.05） ;the serum hs-CRP, NT-proBNP rised higher with NYHA class,LVEF was dropped,there were of statistically significant between different classification in observation group （P〈0.05）;the serum hs-CRP,NT-proBNP with LVEF in observation group was negatively correlated （P〈0.05）. Conclusion In elderly patients with coronary heart disease, the serum hs-CRP, NT- proBNP increased gradually with cardiac function and is of negative correlation with LVEF.