中国大陆地区以-2.0SD为诊断标准的骨质疏松症发病率回顾性研究

A retrospective study of osteoporosis prevalence in China's Mainland using -2.0 SD as diagnosis criteria

目的通过对万方数据与清华CHKD数据库检索,国内已发表骨质疏松症发病率文献进行分析,了解中国大陆地区以-2SD为诊断标准的骨质疏松症发病率。方法在两个数据库检索文献,以"骨质疏松"和"发病率"为主题词,带有各年龄段的男女样本量、测量部位、骨密度值、骨密度检测设备及型号、骨质疏松症发病率等文献。摘录骨质疏松症诊断标准为T值小于-2SD的文献。应用SPSS统计软件对我国骨质疏松发病情况进行分析。结果共检索112篇全文文献,其中14篇文献符合要求,有9篇文献为测量腰椎和股骨颈骨密度。男性样本量为10011例,女性为12943例;40岁-49岁年龄段,女性骨质疏松发病率为7.75%±6.38%,男性为4.0%±2.90%,50岁-59岁年龄段,女性28.0%±15.72%,男性为15.73%±9.49%;60岁-69岁年龄段:女性为52.67%±10.76%。男性为30.55%±10.79%。70岁-79岁年龄段:女性为79.45%±9.53%。男性为43.46%±7.30%。80岁以上年龄段:女性为89.55%±1.04%。男性66.19%±17.56%。结论中国大陆地区男性在各年龄段发病率均低于同年龄段女性发病率,并随年龄患病率逐渐增多,男性与女性的每10年骨质疏松症增长率分别约为15%和20%;40岁以上人群骨质疏松症发病率为24.62%(约25%),约1.4亿患病人群。

Objective To learn osteoporosis prevalence in China's Mainland using - 2.0 SD as diagnosis criteria through analyzing the published literature in China Hospital Knowledge Database （CHKD） and Wanfang database. Methods Using osteoporosis and prevalence as keywords, the related literatures about male and female sample size, measuring site, BMD, the model of DEXA device, and the prevalence of osteoporosis were screened. Literatures using T score - 2.0 SD as diagnosis criteria of osteoporosis were collected. The prevalence of osteoporosis was analyzed using a SPSS software. Results A total of 112 full-text literatures were retrieved, in which 14 literatures met the requirement. BMD of the lumbar vertebrae and the femoral neck was measured using the same type of instrument in 9 of the 14 literatures. The sample size was 10011 cases in men and 12943 in women. The prevalence of osteoporosis was 7.75% ± 6. 38% in women and 4.0% ± 2.90% in men, respectively, in 40 to 49 years old division; 28.0% ± 15.72% in women and 15.73% ± 9.49% in men, respectively, in 50 to 59 years old division; 52.67% ＋_ 10.76% in women and 30.55% ± 10. 79% in men, respectively, in 60 to 69 years old division; 79.45% ± 9.53% in women and 43.46% ± 7.30% in men, respectively, in 70 to 79 years old division; 89.55% ± 1.04% in women and 66. 19% ± 17.56% in men, respectively, in over 80 years old division. Conclusion The osteoporosis prevalence in males is lower than that in females in all age divisions, and it increases rapidly with aging. The increase of osteoporosis prevalence is about 15% in males and 20% in females, respectively. The osteoporosis prevalence is 24. 62% （about 25% ） in over 40 years old population, accounting for about 140 million people.