胃腺癌预后评估中Tiam1蛋白过表达的意义

Prognostic significance of Tiam1 overexpression in gastric adenocarcinoma

目的探讨T淋巴瘤转移诱导因子1(T-cell lymphoma invasion and metastasis-inducing factor 1,Tiam1)过表达在胃腺癌(gastric adenocarcinoma,GAC)临床预后评估中的意义。方法采用免疫组化En Vision法检测Tiam1蛋白在102例GAC组织、21例胃异型增生组织和33例癌旁正常组织中的表达,并分析其过表达与GAC患者预后之间的关系。结果 GAC组织中Tiam1阳性率为85.3%(87/102),强阳性率为61.8%(63/102),均明显高于胃异型增生组织和癌旁正常组织(P均<0.01)。Tiam1蛋白表达水平与GAC分化程度、临床分期、淋巴结转移及浆膜浸润密切相关(P均<0.05),与患者性别、年龄及肿块大小等均无关。结论 Tiam1蛋白表达水平与GAC的发生、发展及预后密切相关,Tiam1蛋白过表达可成为GAC患者不良预后的重要指标之一。

Purpose To investigate the significance of Tiaml protein over-expression in prognostic evaluation of gastric adenocarcinoma （GAC）. Methods Tiaml protein was detected in 102 cases of GAC, 33 dysplasia and 21 dysplasia tissues using immunohistochemi- cal staining. The correlation between Tiaml over-expression and the prognosis of patients with GAC was also analyzed. Results The positive rate and strongly positive rate of Tiaml were 85.3% （87/102） and 61.8% （63/102） in GAC, respectively, and both were significantly higher than those in dysplasia or in dysplasia tissues of cancer （ both P 〈 0. 01 ）. Tiaml expression was significantly corre- lated with the differentiation, clinical stage, LN metastasis, and serosal invasion of GAC （ both P 〈 0. 05 ）, but poorly correlated with the patient＇ s gender, age and tumor size. Conclusions Tiaml expression level is closely related to the progression and prognosis of GAC. High level of Tiaml expression may be used as one of important poor prognostic indicators for GAC.