短暂性脑缺血发作对认知功能的影响研究

Cognitive Function in Patients with Transient Ischemic Attacks

目的探讨短暂性脑缺血发作(transient ischemic attack,TIA)患者的认知功能损伤情况。方法对30例TIA患者和37例健康对照者进行中文版蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)评定和头颅磁共振检查,比较两组患者MoCA测评结果的差异性,并分析其与脑白质损害之间的关系。结果 TIA患者的MoCA量表总分、命名、注意力、语言和延迟记忆评分均显著低于正常对照组(P<0.05),两组间的视空间与执行功能、抽象思维及定向力评分无统计学差异(P>0.05)。TIA组(18/30)脑白质损害比例显著高于正常对照组(12/37,P<0.05)。脑白质损害与MoCA总分、命名、注意力、语言、抽象思维和延迟回忆呈显著负相关(P<0.05)。结论 TIA患者存在不同程度的认知功能损害,其改变可能与脑白质损害有一定的相关性。

Objective To investigate cognitive impairment in patients with transient ischemic attacks （TIA）.Methods Brain magnetic resonance imaging （MRI） and Montreal cognitive assessment （MoCA） were observed in 30 TIA patients and 37 health people. The scores of MoCA in the two groups were compared, and the relationships between cognition im- pairment and white matter damage were analyzed. Results The total scores of MoCA, the score of denomination, attention function, language and delay memory in TIA group were significantly lower than that inthe control group （P〈0.05）. There was no significant difference of visual space executive function, abstract thinking and orientation score between the two groups （P〉0.05）. The TIA group （18/30） had more white matter damage than the control group （ 12/37, P〈0.05）. The negative correlation of white matter damage with the total scores, denomination, attention function, language, ab- stract thinking and delay memory in MoCA were found （P〈0.05）.Conclusion TIA patients have more cognition impair- ment problems. There may be an correlation between cognition impairment and white matter damage.