三阴乳腺癌Ki－67的表达与ER、PR及Her－2的关系研究

The expression of Ki-67 in triple-negative breast cancer and its relationship with ER, PR and Her-2

目的：对Ki－67在三阴性乳腺癌中的表达情况进行研究，并探讨Ki－67与临床病理特征的关系及雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体（Her－2）基因表达间的相关性及临床意义，为临床中乳腺癌的预后判断提供依据，并指导个体化治疗。方法以2012年4月—2014年12月在我院治疗的189例乳腺癌患者为研究对象，其中三阴乳腺癌34例，非三阴乳腺癌155例，采用免疫组织化学法检测189例乳腺癌标本中Ki－67及ER、PR、Her－2的表达。结果 Ki－67在淋巴结有无转移的2组不同乳腺癌组织中的表达差异均有统计学意义，在淋巴结转移的乳腺癌组织中Ki－67的表达阳性率明显高于非淋巴结转移的乳腺癌组织（ P＜0．05）；Ki－67在乳腺癌组织中的表达强度与Her－2的表达强度呈正相关；Ki－67在乳腺癌中的表达强度与激素受体ER、PR表达强度呈负相关。结论 Ki－67分子标志物在三阴性乳腺癌中的表达水平高，乳腺癌中Ki－67的阳性表达提示患者淋巴转移的可能性大。乳腺癌的Ki－67的表达与Her－2基因蛋白表达阳性、激素受体ER、PR阴性表达呈正相关。

Objective To investigate the expression of Ki-67 in triple-negative breast cancer and its relationship with pathological features and estrogen receptor （ ER） , progesterone receptor （ PR） and human epidermal growth factor receptor 2 （ Her-2 ） , in order to provide evidence for clinical prognosis of breast cancer.Methods A total of 189 breast cancer patients were enrolled into the current, who were admitted into our hospital from April 2012 to December 2014.Among them were 34 patients with triple-negative breast cancer and 155 ones with non-triple-negative breast cancer.Then, breast cancer tissue samples were harvested from each patient to measure the levels of Ki-67, ER, PR, and Her-2 by immunohistochemistry.Results Breast cancer tissues with lymph node metastasis showed a significantly higher positive rate of Ki-67 than that of breast cancer tissues without lymph node metastasis （ P〈0.05） .The level of Ki-67 in breast cancer was positively associated with Her-2 expression, and negatively associated with the expression of ER and PR.Conclusion Ki-67 is highly expressed in triple-negative breast cancer, indicating more possibility of lymph node metastasis.The level of Ki-67 in breast cancer is positively associated with Her-2 expression and negative-ly associated with the amounts of ER and PR.