福州市汉族人HLA-B*5801基因多态性与别嘌醇所致严重皮肤不良反应关联性研究

HLA-B*5801 Gene Polymorphism and Allopurinol-induced Severe Cutaneous Adverse Reactions in Han People in Fuzhou

目的探讨别嘌醇所致严重皮肤不良反应(SCAR)与HLA-B*5801基因的关系。方法将服用别嘌醇后致SCAR的21例患者作为别嘌醇SCAR组,30例服用别嘌醇后未出现SCAR的患者作为别嘌醇耐受组,另选取53例健康体检者作为正常对照组。对2组患者及正常对照组血液进行HLA-B*5801基因检测,观察其HLA-B*5801阳性基因例数及频率。结果别嘌醇SCAR组、别嘌醇耐受组及正常对照组的HLA-B*5801阳性基因数分别为19,4和10例。别嘌醇SCAR组HLA-B*5801阳性基因频率显著高于别嘌醇耐受组,2组比较差别有统计学意义[OR=61.75,95%CI(10.23,372.64),P<0.001];别嘌醇SCAR组HLA-B*5801阳性基因频率显著高于正常对照组,2组比较差别有统计学意义[OR=40.85,95%CI(8.16,204.64),P<0.001]。结论福州市汉族人服用别嘌醇所致SCAR与HLA-B*5801基因有关。

Objective To investigate correlation between allopurinol-induced severe cutaneous ad verse reactions（SCAR） and the HLA-B＊ 5801 gene polymorphism. Methods The study used twenty-one cases suffering from allopurinol induced SCAR as allopurinol SCAR group, thirty cases of patients who took allopurinol yet without SCAR as allopurinol tolerance group. Further, the study included fifty-three healthy persons as the control group. This study detected HLA-B＊ 5801 and calculated its frequency in the blood of the following groups allopurinol SCAR group with severe adverse derma reaction, allopurinol tolerance group, and normal healthy group. Results There were nineteen cases of HLA-B＊ 5801 positive in allopurinol SCAR group, four cases in allopurinol tolerance group, and ten positive cases in the normal healthy group. The allopurinol SCAR group had a significant high frequency in HLA-B＊ 5801 gene poly- morphism than the allopurinol tolerance group, and the difference between them was statistically signifi- cant[OR=61. 75,95% CI（10.23,372. 64）,P〈0. 001]; the HLA-B＊ 5801 positive frequency in the allo- purinol SCAR group with severe adverse derma reaction was also higher than the normal healthy group, and the difference between them had statistical significance[OR = 40. 85, 95% CI（8. 16,204. 64）, P〈0. 0011. Conclusion The frequency of allopurinol-induced SCAR was related to HLA-B＊ 5801 gene polymorphism in Han people in Fuzhou.