乌司他丁治疗小儿重症急性胰腺炎的疗效观察

Clinical Observation of Ulinastatin in the Treatment of Severe Acute Pancreatitis in Children

目的:探讨分析乌司他丁治疗小儿重症急性胰腺炎的疗效。方法:选取本院2011年1月-2015年1月收治的70例重症急性胰腺炎儿童作为研究对象,按照治疗方式的不同将其分为观察组和对照组,每组各35例。对照组给予单纯常规治疗,观察组在常规治疗的基础上加用乌司他丁,比较两组的治疗效果以及IL-6、IL-10含量。结果:经治疗后,观察组总有效率为97.14%,对照组总有效率为57.14%,两组比较差异有统计学意义(P<0.05);观察组的IL-6下降速度明显快于对照组,IL-10升高速度也显著快于对照组,两组比较差异均有统计学意义(P<0.05)。结论:乌司他丁治疗小儿重症急性胰腺炎效果显著,能明显的抑制炎性反应蛋白CRP,通过调节IL-6、IL-10等细胞因子含量促使病情好转,值得临床推广和应用。

Objective： To investigate the effect of Ulinastatin in the treatment of severe acute pancreatitis in children.Method： 70 children with severe acute pancreatitis were selected as the research objects from January 2011 to January 2015, according to the different treatment modalities, they were divided into the observation group and the control group , 35 cases in each group. The control group was given routine treatment, the observation group on the basis of conventional therapy was given Ulinastatin.The therapeutic effect, the content of IL-10 and IL-6 of the two groups were compared. Result： After treatment, the total effective rate of the observation group was 97.14%, the control group was 57.14%, the difference between two groups was statistically significant （ P〈 0.05 ） ; the dropping speed of IL-6 in the observation group was significantly faster than that in the control group and the increasing speed of IL-10 was significantly faster than the control group, the differences were statistically significant （P〈0.05） .Conclusion： The effect of Ulinastatin in the treatment of children With severe acute pancreatitis is significant, can significantly inhibit inflammatory reaction protein （ CRP ）, through the regulation of IL-6 and IL-10 cytokine content prompting condition improved, it is worthy of the clinical promotion and application.