黄连地榆汤配方颗粒治疗溃疡性结肠炎的临床观察

Clinical Observation on the Granules Based on the Formula of Huanglian Diyu Tang for Treating Ulcerative Colitis

为观察黄连地榆汤配方颗粒治疗溃疡性结肠炎的临床疗效，将溃疡性结肠炎60例随机分为试验组和对照组各30例。试验组给予黄连地榆汤配方颗粒灌肠与H服，对照组应用锡类散灌肠。20d为1个疗程，共治疗2个疗程。评价两组治疗前后综合疗效、内镜下黏膜疗效、黏膜病理疗效和不良反应指标。结果显示，治疗后试验组在综合疗效、内镜下疗效、黏膜病理疗效均优于对照组（P〈0．05），试验组不良反应的发生率较对照组低。结果表明，黄连地榆汤配方颗粒灌肠联合1：3服临床疗效显著，不良反应率发生低，与单用锡类散灌肠相比具有明显优势。

This study was to observe the clinical effect of the granules based on the formula of Huanglian Diyu Tang（a decoction of Chinese drugs） for treating ulcerative co itis（UC）.The 60 patients with UC were randomly divided into trial group and control one, 30 cases for each;the former adopted above granules for enema,and oral administered them,while the latter, received enema with Xilei San（Chinese drugs powder） ;20 days as a treatment course,for 2 courses totally; then the combined effect（before and after treat- ment）, endoscopy mucosa effect, mucosa pathol6gical effect, and adverse reaction, and so on were observed and evaluated.As results,in first 3 items the former was all superior to the latter（ P 〈0.05）,and its ad- verse reaction incidence was low than the latter. Results show that enema plus oral administration of above granules for treating UC has significant effect,low incidence of adverse reaction,thus has distinct predomi- nance than Xilei San.