托拉塞米治疗慢性肺源性心脏病致严重右心衰疗效观察

The Application of Torasemide Injection in Patients with Severe Right Heart Failure

目的:通过对比托拉塞米注射液与呋塞米注射液的利尿作用,探讨托拉塞米注射液在慢性肺源性心脏病致严重右心衰竭患者应用价值。方法:选取慢性肺源性心脏病致严重右心衰患者60例,随机分为托拉塞米组(30例)和呋塞米组(30例),在常规治疗基础上,两组分别用托拉塞米注射液20 mg·d-1与呋塞米注射液20 mg·d-1治疗。观察比较两组患者治疗后水肿消退时间、血钾的变化和右心功能改变。结果:治疗后,与呋塞米组比较,托拉塞米组水肿消退时间短,差异有统计学意义(P<0.05);托拉塞米组血钾下降较少,差异有统计学意义(P<0.05);右心功能有一定改善,差异无统计学意义。结论:托拉塞米注射液治疗慢性肺源性心脏病致严重右心衰疗效好,不良反应轻、少。

Objective： To explore the application value of torasemide injection in patients with severe right heart failure caused by chronic cor pulmonale by comparing its diuretic effect with furosemide. Methods ： 60 patients with severe right heart failure caused by chronic cor pulmonale were randomly divided into torasemide group （30 cases） and furosemide group （30 cases）. On the basis of conventional treatment, two groups separately were treated with injection 20 mg·d^-1 and furosemide injection 20 mg·d^-1. Serum potassium change, right heart function and edema regression time in the two groups before and after treatment were measured. Results ： Edema regression time was significantly decreased in torasemide group than that in furoeemide group （ P 〈 0.05 ）. The serum potassium decline in torasemide group was slightly less than in furoeemide group （ P 〈 0.05 ）. There were statistically significant differences. There was no statistical difference between the right heart function improvements of the two groups. Conclusion： It has good curative effect to treat patients with severe right heart failure caused by chronic car pulmonale, with less adverse reaction.