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骨髓间充质干细胞治疗脊髓损伤的研究进展 被引量：5

Bone marrow mesenchymal stem cells in the treatment of spinal cord injuries: a review
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摘要 骨髓间充质干细胞（bone marrow mesenchymal stem cells,BMSCs）因具有取材方便、能够自体移植、无免疫源性、不受伦理学限制等特征成为治疗脊髓损伤的种子细胞之一[1、2],BMSCs治疗脊髓损伤的机制主要有分化为神经样细胞、抑制炎症反应、神经营养作用及促进轴突再生[3、4]。早期临床实验表明BMSCs移植治疗脊髓损伤安全、有一定疗效[5]。
作者 李昂 李波 魏志坚 冯世庆
机构地区 天津医科大学总医院骨科
出处 《中国脊柱脊髓杂志》 CAS CSCD 北大核心 2016年第1期90-94,共5页 Chinese Journal of Spine and Spinal Cord
关键词 脊髓损伤 神经样细胞 神经营养作用 轴突再生 免疫源性 间充质干细胞 激活态雪旺细胞 胶质瘢痕 种子细胞 诱导分化
分类号 R683.2 [医药卫生—骨科学] Q813 [生物学—生物工程]
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  • 1Baba H, Sakurai M, Abe K, Tominaga R (2009) Autophagy-mediated stress response in motor neuron after transient ischemia in rabbits. J Vasc Surg 50:381-387.
  • 2Bock P, Spitzbarth I, Haist V, Stein VM, Tipold A, Puff C, Beineke A, Baumg~irtner W (2013) Spatio-temporal development of axonopathy in canine intervertebral disc disease as a translational large animal model for nonexperimental spinal cord injury. Brain Patho123:82-99.
  • 3Cakir O, Erdem K, Oruc A, Klhnc N, Eren N (2003) Neuroprotective effect of N-acetylcysteine and hypothermia on the spinal cord isch- emia-reperfusion injury. Cardiovasc Surg 11:375-379.
  • 4Cali6 ML, Marinho DS, Ko GM, Ribeiro RR, Carbonel AF, Oyama LM, Ormanji M, Guirao TP, Cali6 PL, Reis LA, Sim6es Mdl, Lisb6a-Na- scimento T, Ferreira AT, Bertoncini CRA (2014) Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model. Free Radic Biol Med 70:14 1- 154.
  • 5Citron BA, Arnold PM, Sebastian C, Qin F, Malladi S, Ameenuddin S, Landis ME, Festoff BW (2000) Rapid upregulation of caspase-3 in rat spinal cord after injury: mRNA, protein, and cellular localization correlates with apoptotic cell death. Exp Neurol 166:213-226.
  • 6Coleman MP, Perry VH (2002) Axon pathology in neurological disease: a neglected therapeutic target. Trends Neurosci 25:532-537.
  • 7Da Silva J, Hare l (2013) Cell-based therapies for myocardial repair: emerging role for bone marrow-derived mesenchymal stem cells (MSCs) in the treatment of the chronically injured heart. Methods Mol Biol 1037:145-163.
  • 8Dawson DA, Hallenbeck JM (1996) Acute focal ischemia-induced alter- ations in MAP2 immunostaining: description of temporal changes and utilization as a marker for volumetric assessment of acute brain injury. J Cereb Blood Flow Metab 16:170-174.
  • 9Deumens R, Koopmans GC, loosten EAI (2005) Regeneration of de- scending axon tracts after spinal cord injury. Prog Neurobiol 77:57- 89.
  • 10Gao X, Song L, Shen K, Wang H, Qian M, Niu W, Qin X (2014) Bone marrow mesenchymal stern cells promote the repair of islets from di- abetic mice through paracrine actions. Mol Cell Endocrinol 388:41- 50.

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中国脊柱脊髓杂志
2016年 第1期

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