不同治疗结局IVF-ET患者心理状况分析

Analysis of psychological status of IVF-ET patients with different treatment outcome

目的了解体外受精-胚胎移植(IVF-ET)患者在不同治疗结局情况下的焦虑、抑郁状况,为临床治疗中是否需要对患者进行心理干预提供依据。方法 558例IVF-ET患行进行现场一般资料、焦虑自评量表(SAS)、抑郁自评量表(SDS)问卷调查,分析不同的治疗结局患者的心理状况。结果①妊娠组与未妊娠组患者一般情况比较,差异无统计学意义。②未妊娠组患者焦虑、抑郁评分为(47.14±7.19)、(50.51±10.55)分,稍高于妊娠组,但无显著性差异;未妊娠组患者焦虑症状检出率(23.8% vs 13.2%)、抑郁症状检出率(44.8% vs 27.2%)显著高于妊娠组(P=0.001,P<0.001)。③妊娠组、未妊娠组患者焦虑、抑郁症状检出率回归分析,焦虑对妊娠影响差异无统计学意义(OR=0.665,P=0.097),抑郁对于妊娠有负相关性(OR=0.523,P=0.001)。④未妊娠组抑郁症状多因素Logistic回归分析,较长的不孕年限(OR=2.050,P=0.010)、较长的治疗周期(OR=2.036,P=0.004)是抑郁的危险因素,而较高的家庭年收入(OR=0.373,P=0.006)则是抑郁的保护性因素结论 IVF-ET患者抑郁对治疗结局的影响较大;不孕年限、治疗周期次数、家庭年收入是IVF-ET未妊娠的抑郁患者的影响因素。临床需对IVF-ET抑郁患者行心理于预,提高临床妊娠率。

Objective To investigate the anxiety and depression of patients with in vitro fertilization and embryo transfer （IVF-ET） in different treatment outcome, and to provide the basis for clinical psychological intervention. Methods 558 patients with IVF-ET on-site general information, self-evaluation anxiety scale （SAS） and Zung Depression self rating scale （SDS） questionnaire and analysis of different treatment outcomes in patients with heart conditions. Results （1） There was no significant difference between the pregnant group and the non pregnant group. （2） Non pregnant patients anxiety, depression scores were （47.14± 7.19）, （50.51 ±10.55）, slightly higher than that of the pregnancy group, but there was no significant difference ; the detection rate of anxiety symptoms（23.8% vs 13.2% ）and the detection rate of depressive symptoms（44.8% vs 27.2% ）,the non pregnant group were significantly higher than those in the pregnant group ,respectively （P =0. 001 ,P 〈0. 001 ）. （3） The detection rate of anxiety and depressive symptoms in pregnancy group and non pregnancy group, anxiety had no signif- icant effect on pregnancy （ OR = 0. 665, P = 0. 097 ） , the effect of depression on pregnancy was negative （ OR = 0. 523 ,P = 0. 001 ）. （4） No pregnancy symptoms of depression group multivariate logistic regression analysis, longer duration of infertility （ OR =2. 050,P =0. 010）, long treatment cycle （ OR =2. 036, P =0. 004） were the risk factors of depression, and higher family income （ OR = 0. 373,P = 0. 006） was depressed protective factors. Conclusion IVF-ET have bigger influence on treatment outcome in patients with depression; the length of infertility, the number of treatment cycles, and family income were the influencing factors of IVF-ET in patients with depression. Clinical need to IVF-ET depression in patients with psychological intervention, improving the clinical pregnancy rate.