Stathmin在胰腺癌中的表达及意义

Clinical significance of expression of stathmin in pancreatic cancer

目的探讨Stathmin在胰腺癌中的表达水平以及与临床、病理特征方面的关系。方法通过免疫组化法和原位杂交技术分别检测40例胰腺癌癌组织、27例胰腺癌旁正常组织中Stathmin及其mRNA的表达情况。结果 Stathmin在胰腺癌癌组织的阳性率显著高于胰腺癌旁正常组织(77.5%vs 7.4%),差异有统计学意义(P<0.05);Stathmin mRNA的表达阳性率也明显高于癌旁正常组织(80.0% vs7.4%),差异有统计学意义(P<0.05)。不同分化程度、有无淋巴结转移、有无远处转移以及TNM分期等方面胰腺癌组织之间的Stathmin表达差异均有统计学意义(P<0.05)。结论 Stathmin及其mRNA在胰腺癌组织的高水平表达,与胰腺癌的分化程度、淋巴结转移、远处转移及TNM分期密切相关,提示Stathmin可能参与了胰腺癌发生、发展,Stathmin对胰腺癌的早期诊断及预后判断有重要意义。

Objective To investigate the relationship between the clinicopathological features and Stathmin expres- sion in pancreatic cancer. Methods Expressions of Stathmin and Stathmin mRNA were detected in 40 pancreatic cancer samples, 27 adjacent normal samples of pancreatic cancer by immunohistochemistry and in situ hybridization, respectively. Results Stathmin positive rate in pancreatic cancer samples was significantly higher than that of adjacent normal samples of pancreatic cancer （77.5% vs 7.4% , P 〈 0.05 ） ; the positive rate of Stathmin mRNA expression was also higher than that of adjacent normal samples of pancreatic cancer （80. 0% vs 7.4% ,P 〈 0. 05）. Stathmin expression levels were signifecantly correlated to the differentiation degree , lymph node metastasis, distant metastasis and TNM staging for pancreatic cancer （ P 〈 0. 05 ）. Conclusion Higher expression of Stathmin and mRNA in pancreatic cancer were closely related to the differentiation degree for pancreatic cancer , lymph node metastasis, distant metastasis and TNM staging , suggesting Stathmin may be involved in oncogenesis of pancreatic cancer. Stathmin may play important roles in early diagnosis and prognosis of pancreatic cancer.