NT-proBNP、Hcy及hs-CRP水平变化与急性冠状动脉综合征的相关性

Correlation between changes of NT-proBNP,Hcy and hs-CRP levels and acute coronary syndrome

目的:研究NT-proBNP、Hcy及hs-CRP水平变化与急性冠状动脉综合征的相关性。方法:选择健康志愿者、稳定型心绞痛患者、急性冠脉综合征患者各40例进行研究,分别纳入健康对照组、SAP组、ACS组,采集血清标本并测定NT-proBNP、Hcy、hs-CRP、炎性因子以及氧化应激指标。结果:ACS组患者血清中NT-proBNP、Hcy、hs-CRP的水平高于SAP组、对照组,病情越严重、病变冠脉数目越多,血清NT-proBNP、Hcy、hs-CRP水平升高越明显;ACS患者的血清IL-6、IL-12、IL-18、IL-23、MMP2、MMP9、ox-LDL、8-isoPGF2α水平明显高于SAP组和对照组且与NT-proBNP、hs-CRP、Hcy水平呈正相关;ACS患者的血清GSH、NADPH、SOD、ALDH2的水平低于SAP组和对照组且与NTproBNP、hs-CRP、Hcy水平呈负相关。结论:急性冠状动脉综合征患者血清中NT-proBNP、Hcy及hsCRP水平含量显著升高且与病情严重程度、病变冠脉数目以及炎症反应程度、氧化应激反应程度相关。

Objective： To study the correlation between changes of NT-proBNP, Hcy and hs-CRP levels and acute coronary syndrome. Methods： Forty cases each of healthy volunteers, patients with stable angina pectoris and patients with acute coronary syndrome were selected for study and enrolled in healthy control group, SAP group and ACS group respectively, and serum specimens were collected to detect NT-proBNP, Hcy, hs-CRP, inflammatory factors and oxidative stress indicators. Results ： Serum NT-proBNP, Hey and hs-CRP levels of ACS group were significantly higher than those of SAP group and con trol group, and the more severe the disease and the more coronary artery lesions indicated more significant increase in serum NT-proBNP, Hcy and hs-CRP levels. Serum IL-6, IL 12, IL-18, IL-23, MMP2, MMP9, ox-LDL and 8-isoPGF2a levels of ACS group were significantly higher than those of SAP group and control group and positively correlated with NT proBNP, hs CRP and Hey levels. Serum GSH, NADPH, SOD and ALDH levels of ACS group were lower than those of SAP group and control group and negatively correlated with NT proBNP, hs-CRP and Hey levels. Conclusion： Serum NT-proBNP, Hey and hs-CRP levels in patients with acute coronary syndrome increase significantly and are correlated with the severity of disease, number of coronary artery lesions, degree of inflammatory response, and degree of oxidative stress response.