恩度联合动脉灌注化疗栓塞(TACE)治疗后原发性肝癌恶性程度的评估

Evaluation of malignant degree of primary hepatocellular carcinoma after endostar combined with transcatheter arterial chemoembolization(TACE)treatment

目的:分析恩度联合动脉灌注化疗栓塞(TACE)治疗后原发性肝癌的恶性程度。方法:将本院收治的原发性肝癌患者68例纳入研究,根据治疗方式不同分为观察组及对照组各34例。对照组接受动脉灌注化疗栓塞(TACE)治疗,观察组接受恩度联合TACE治疗,对比两组治疗后血清氨基酸水平,微小RNA水平,GP73、GPC3、GS等水平,ChE、TBA、AFP水平等差异。结果:观察组接受治疗后的血清天门冬氨酸、亮氨酸、精氨酸水平高于对照组,α氨基己二酸、蛋氨酸、β-丙氨酸、3-甲基组氨酸水平低于对照组(P<0.05);观察组治疗后血清miR-106b、miR-222、miR-21表达相对值低于对照组,miR-199a、miR-122表达相对值高于对照组(P<0.05);观察组接受治疗后的GP73、IL-17、IL-6、GPC3、GS、HSP70水平低于对照组,内皮抑素水平高于对照组(P<0.05);观察组接受治疗后的ChE水平高于对照组,TBA、AFP水平低于对照组(P<0.05)。结论:原发性肝癌患者接受恩度联合TACE治疗,可以有效抑制肿瘤增殖侵袭等恶性进程,提升肝功能,具有积极的临床意义。

Objective： To analyze the malignant degree of primary hepatocellular earcinoma after treatment of endostar combined with transcatheter arterial chemoembolization （TACE） treatment. Methods= A total of 68 patients with primary hepatocellular carcinoma treated in the hospital were enrolled for study and divided into observation group and control group with 34 cases in each group according to different treatment methods. Control group received TACE treatment, while observation group received endostar combined with TACE treatment, and then differences in levels of serum amino acid, micro-RNA,GP73, GPC3, GS, etc. , as well as levels of ChE, TBA and AFP were compared between two groups after treatment. Results Serum aspartic acid, leueine and arginine levels in observation group after treatment were higher than those in control group, and α-aminoadipic acid, methionine, 13-alanine and 3-methylhistidine levels were lower than those in control group （P〈0.05） ; relative values of serum miR-106b, miR-222 and miR-21 expression in observation group after treatment were lower than those in control group, and relative values of miR 199a and miR-122 expression were higher than those in control group （P〈0.05） ; GP73, II. 17, IL-6, GPC3, GS and HSPT0 levels in observation group after treatment were lower than those in control group, while endostatin level was higher than that in control group （P〈0.05） ChE level in observation group after treatment was higher than that in control group, and TBA and AFP levels were lower than those in control group （P〈0.05）. Conclusions： Endostar combined with TACE treatment for patients with primary hepatoceUular carcinoma can effectively inhibit tumor proliferation, invasion and other malignant processes and improve liver function, with a positive clinical significance.