组织工程用人工支架表面改性的研究进展

Advances in the surface modification of artificial scaffolds for tissue engineering

组织工程用人工支架有着完美的三维结构、良好的细胞相容性和特殊的药理作用,一直受到生命科学和工程领域专家的重视。人工支架的表面改性研究关系到细胞生长、繁殖及迁移等状态,是组织工程的基础及热点。与普通人工支架相比,改性支架除了赋予细胞更好的黏附、增殖、迁移性能外,还赋予支架药物洗脱性能,使之能促进细胞生长或抑制病变细胞繁殖,为组织工程的设计研究提供了更广阔的应用空间。文章概述组织工程用人工支架表面改性的分类、制备方法、结构和性能,展望人工支架表面改性研究的前景。

Artificial scaffold for tissue engineering has perfect three-dimensional structure, good cell compatibility and special pharmacological effects, which attracts much attention from the experts in the field of life science and engineering. Artificial stent surface modification research, relating to cell proliferation migration status, is the basis and focus of tissue engineering. Compared with ordinary artificial scaffolds, modified stents not only give cell excellent properties such as good adhesion, proliferation, migration performance, but also have the drug-eluting stents performance which can promote cell growth or the inhibition of diseased cells reproduce, providing a broader application space for the design and research of tissue engineering. The classification, preparation method, structure and properties of surface modification for the artificial scaffolds were summarized and the prospect of the research of the stent surface modification was proposed.