HSPC238在宫颈上皮内瘤变和宫颈癌中的表达与意义

Expression and significance of HSPC238 in cervical intraepithelial neoplasia and cervical cancer

目的:检测HSPC238在宫颈上皮内瘤变和宫颈癌中的表达。方法:收集76例宫颈癌、105例CIN及28例正常宫颈标本,采用免疫组织化学的方法检测HSPC238的表达,比较不同组织中HSPC238表达的差异。结果:正常组织和癌组织中的HSPC238的表达强度无显著差异(Z=-0.242,P>0.05)宫颈上皮内瘤变组织(CINⅠ,CINⅡ,CINⅢ)与正常组织有显著差异(χ2=19.159,P<0.01),并且发现HSPC238的表达与CIN的分级存在显著相关性,随着CIN级别升高,染色程度降低(rs=-0.327,P<0.01)。结论:HSPC238的低表达与宫颈肿瘤的发生发展可能有一定关系。

Objective： To investigate the expression of HSPC238 in cervical intraepithelial neoplasia and cervical cancer. Methods： We collected 76 cases of cervical cancer, 105 cases of CIN and 28 cases of normal cervical epithelial. Then we investigated the expression of HSPC238 by using immunobistochemistry and compared the significant differences between them. Results： There was no significant difference in the expression of HSPC238 between the cervical cancer and normal cervical epithelial （Z=- 0. 242,P〉0. 05 ）. However, there was significant difference between the cervical intraepithelial neoplasia and normal cervical epithelial （X2= 19. 159 ,P〈0.01 ）and the expression of HSPC238 was correlated with the grades of CIN. The expression of HSPC238 decreased when the grade of CIN was increasing. （rs = -0. 327, P〈0.01 ）. Conclusion： The low expression of HSPC238 might be correlated with the development of cervical neoplasia.