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TIM-3在慢性HBV感染中的免疫调节作用 被引量:6

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摘要 慢性乙型肝炎病毒(Hepatitis B virus,HBV)感染是世界范围内最常见的慢性病毒性感染,全球约有20亿人口有血清学证据证实现症或既往感染HBV,其中约3.5亿人口罹患慢性HBV感染[1,2];慢性HBV感染可致慢性肝病,与肝硬化、肝癌的发生密切相关,在2010年全球疾病负担研究中,HBV感染位居首位,在导致死亡的病因中位列第10(78.6万/年)[3],基于这些数据,
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2016年第2期267-270,274,共5页 Chinese Journal of Immunology
基金 浙江省医药卫生一般研究计划(2012KYB237)基金资助
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  • 1Jones RB,Ndhlovu LC,Barbour JD, et al.Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection[].The Journal of Experimental Medicine.2008
  • 2Anderson DE.TIM-3 as a therapeutic target in human inflam- matory diseases[].Expert Opinion on Therapeutic Patents.2007
  • 3Wang Y,Meng J,Wang X, et al.Expression of human TIM-1 and TIM-3 on lymphocytes from systemic lupus erythematosus patients[].Scandinavian Journal of Immunology.2008
  • 4Wada J,Kanwar YS.Identification and characterization of galectin-9, a novel β-galactoside-binding mammalian lectin[].Journal of Biological Chemistry.1997
  • 5Monney L,Sabatos CA,Gaglia JL,et al.Th1-specific cell surface protein Ti m-3regulates macrophage activation and severity of an autoi mmune disease[].Nature.2002
  • 6Sabatos CA,Chakravarti S,Cha E,et al.Interaction of Ti m-3and Ti m-3ligand regulates T helper type1responses and induction of peripheral tolerance[].Nature Immunology.2003
  • 7Sanchez-Fueyo A,Tian J,Picarella D, et al.Tim-3 inhibits T helper type 1-mediated auto-and alloimmune responses and promotes immunological tolerance[].Nature Immunology.2003
  • 8Zhu C,Anderson AC,Schubart A,et al.The Ti m-3ligand galectin-9negatively regulates T helper type1i mmunity[].Nature Immunology.2005
  • 9Anderson A C,Anderson D E,Bregoli L,et al.Promotion oftissue inflammation by the immune receptor Tim-3 expressedon innate immune cells[].Science.2007
  • 10Oikawa T,Kamimura Y,Akiba H,et al.Preferential involve-ment of Tim-3 in the regulation of hepatic CD8+T cells in mu-rine acute graft-versus-host disease[].J Immunol.2006

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