经肝动脉化疗栓塞术联合干扰素治疗中晚期原发性肝癌疗效的Meta分析

Effect of transcatheter arterial chemoembolization combined with interferon adjuvant therapy in treatment of advanced primary liver cancer: a meta-analysis

目的评价干扰素(IFN)辅助经肝动脉化疗栓塞术(TACE)治疗中晚期原发性肝癌患者的疗效,为TACE术后辅助治疗提供思路。方法利用计算机检索Cochrane图书馆、Pub Med、Medline、Embase、CNKI、万方、维普等数据库2015年1月以前的文献,纳入所有国内外期刊公开发表的关于TACE联合IFN对比TACE单独治疗中晚期原发性肝癌的随机对照试验。对纳入文献进行质量评价和资料提取,采用Revman 5.1软件进行Meta分析。结果共纳入6篇文献,包括IFN辅助治疗组311例和安慰剂组308例患者。分析结果显示,IFN辅助治疗组的1、2、3年复发率均比安慰剂组低,1年生存率比安慰剂组高,差异均有统计学意义(P值分别为0.006、0.002、0.002、0.030)。结论 IFN辅助治疗能降低TACE术后肝癌的复发风险,提高患者的生存率。

Objective To investigate the effect of transcatheter arterial chemoembolization （TACE） combined with interferon （IFN） adju- vant therapy in the treatment of advanced primary liver cancer, and to provide new ideas for adjuvant therapies after TACE. Methods The databases including Cochrane Library, PubMed, Medline, Embase, CNKI, Wanfang Data, and VIP were searched to obtain all articles pub- lished before January 2015, and the randomized controlled trials （RCTs） about the comparison between TACE combined with IFN and TACE alone published in journals at home and abroad were included. Quality assessment and data extraction were performed for these articles, and Revman 5.1 software was applied for the meta - analysis. Results A total of 6 RCTs were included, consisting of 311 patients in the IFN adjuvant therapy group and 308 patients in the placebo group. The results of the meta - analysis showed that compared with the placebo group, the IFN adjuvant treatment group had significantly lower 1 - , 2 - , and 3 - year recurrence rates and a significantly higher 1 - year survival rate （P = 0. 006, 0.002, 0. 002, and 0.030）. Conclusion IFN adjuvant therapy can reduce the risk of liver cancer recurrence after TACE and improve the patients＇ survival rate.