颅内动脉瘤患者中性粒细胞与淋巴细胞比值和Hunt-Hess分级的相关性分析

Correlation between neutrophil to lymphocyte ratio and Hunt-Hess grade of patients with intracranial aneurysm

目的 ：检测颅内动脉瘤患者中性粒细胞与淋巴细胞比值（neutrophil to lymphocyte ratio,NLR）水平,探索其联合HuntHess分级对颅内动脉瘤患者临床状态的评估价值。方法 ：选取颅内动脉瘤患者220例,其中破裂颅内动脉瘤（ruptured intracranial aneurysm,RIA）组127例、未破裂颅内动脉瘤（unruptured intracranial aneurysm,UIA）组93例,应用静脉血中性粒细胞绝对值与淋巴细胞绝对值的比值表示NLR,Hunt-Hess分级初步评估病情严重程度。测定不同Hunt-Hess分级NLR水平,对NLR与Hunt-Hess分级的关系采用Spearman’s rho相关分析。结果：RIA组NLR与UIA组相比明显增高（P=0.000）;Hunt-HessⅠ-Ⅴ级组NLR均较0级组明显增高（P〈0.05）,Ⅲ-Ⅴ级组NLR均较Ⅰ-Ⅱ级组明显增高（P〈0.05）;而Ⅰ和Ⅱ级以及Ⅲ和Ⅳ级组间NLR相比差异均无统计学意义（P〉0.05）;NLR与Hunt-Hess分级呈正相关（r=0.768,P=0.000）。结论 ：外周血NLR可能与颅内动脉瘤破裂相关,Hunt-Hess分级联合NLR可能能更准确地综合评估颅内动脉瘤患者病情严重程度及预后。

Objective：To investigate the peripheral blood of neutrophil to lymphocyte ratio（NLR）levels in patients with intracranial aneurysm（IA）and to assess the risk of IA with the combination of Hunt-Hess grade and NLR. Methods：Totally 220 patients in our hospital from January 2014 to May 2015 were selected in the study and were divided into two groups：127 in ruptured intracranial aneurysm（RIA）group and 93 in unruptured intracranial aneurysm（UIA）group according to rupture. White blood cell（WBC）and its subtypes were obtained from venous blood. NLR was computed by taking the absolute neutrophil count and NLR was divided by the absolute lymphocyte count. The severity of IA was preliminarily evaluated using the Hunt-Hess grade. NLR in the six grades were measured. Correlation between NLR and Hunt-Hess grade was analyzed by Spearman ＇s rho correlation analysis. Results：Clinical characteristics were comparable between the two groups（P〉0.05）. Compared with those of the UIA group,both WBC and NLR in the RIA were significantly higher（P=0.000,P=0.000）. Compared with those in Hunt-Hess 0 grade,NLR in Ⅰ-Ⅴ were increased and NLR in Hunt-Hess Ⅲ-Ⅴ grades were higher than those in Ⅰ-Ⅱ grades,respectively（P〈0.05）. NLR was positively correlated with HuntHess grade（r=0.768,P=0.000）. Conclusion：NLR might be associated with the rupture risk of IA;combination of Hunt-Hess grade and NLR might assess the severity of IA and predict its prognosis accurately.