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超声靶向微泡破坏技术评价心肌缺血再灌注损伤的研究进展

Progress of ultrasound- targeted microbubble destruction technology in evaluation of myocardial ischemia- reperfusion injury
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摘要 心肌缺血再灌注损伤是指原缺血心肌恢复血供后发生更为严重的损伤,再灌注损伤减弱了再灌注给机体带来的益处。心肌缺血再灌注损伤在靶向超声分子显像技术中有多种研究,包括超声靶向破坏微泡技术对心肌缺血再灌注的评价与介导靶向治疗,其中携IL-8单克隆抗体的超声靶向微泡破坏技术可明显减轻再灌注后炎症反应引起的损伤,减轻心肌坏死程度。 Myocardial ischemia-reperfusion injury refers to more severe injury occurred after recovery from previous myocardial ischemia,which reduces the benefit induced by reperfusion. Effects of targeted ultrasound molecular imaging technology on myocardial ischemia-reperfusion injury has been researched a lot,including evaluation for myocardial ischemia- reperfusion by ultrasound-targeted microbubble destruction as well as mediating targeted therapy, among which, IL-8 monoclonal antibody based ultrasound-targeted microbubble destruction could significantly reduce the injury caused by inflammation after reperfusion injury, and reduce myocardial necrosis.
作者 孙月 陆永萍
机构地区 云南省第二人民医院超声科
出处 《临床超声医学杂志》 2016年第2期112-114,共3页 Journal of Clinical Ultrasound in Medicine
基金 国家自然科学基金(81460062)
关键词 靶向微泡破坏 心肌缺血 再灌注损伤 超声 Targeted microbubble destruction Myocardial ischemia Reperfusion injury Ultrasound
分类号 R541.9 [医药卫生—心血管疾病] R445.1 [医药卫生—影像医学与核医学]
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参考文献27

  • 1Deshpande N, Lutz AM, Ren Y, el al.Quantficatjon and monitoring of inflammation in mu rine inflammatory bowel disease with targeted contrast-enhanced US[J].Radiology ,2012, 262( 1): 172-180.
  • 2Anderson CR, Hu X, Zhang H, et aI. Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent[J].lnvest Radiol, 2011 ,46( 4): 215-224.
  • 3Deshpande N , Ren Y ,Foygel K, et al . Tumor angiogenic marker expression levels during tumor growth: longitudinal assessment with molecularly targeted microbubbles and US imaging [J] . Radiology , 2011,258(3):804-811.
  • 4Klibanov A1.Preparation of targeted microbubbles: ultrasound contrast agents for molecular imaging [J l. Med BioI Eng Comput, 2009 ,47 ( 8 ) : 875-882.
  • 5Hyvelin JM, Tardy I ,Bettinger T ,et al.Ultrasound molecular imaging of transient acute myocardial ischemia with a clinically translatable P?and E-selectin targeted contrast agent: correlation with the expression of selectins [J] .Invest Radiol, 2014,49 ( 4 ) : 224-235.
  • 6Thomas R,Cheng Y, Yan J ,et al.Upregulation of coronary endothelial P - selectin in a monkey heart ischemia reperfusion model [J] . J Mol Histol , 2010,41 ( 4-5) : 277 - 287.
  • 7Lindner JR, Coggins MP, Kaul S, et al.Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin-and complement-mediated adherence to activated leukocytes[J].Circulation, 2000, 101 (6): 668-675.
  • 8Kaufmann BA, Lewis C, Xie A, et al.Detection of recent myocardial ischaemia by molecular imaging of P -selectin with targeted contrast echocardiographyj Jj.Eur Heart J ,2007 ,28( 16) :2011-2017.
  • 9Klibanov AL. Ultrasound molecular imaging with targeted microbubble contrast agents[J]. J Nucl Cardiol,2007, 14(6) :876-884.
  • 10Kaufmann BA, Lewis C, Xie A, et al. Detection of recent myocardial ischaemia by molecular imaging of P -selectin targeted contrast echocardiographyl Jj.Eur Heart J ,2007 ,28( 16) :2011-2017.

二级参考文献58

  • 1吕刚,韩笑,张秀娟,徐卫平,杜培革.半胱氨酰白三烯受体的研究进展[J].吉林医药学院学报,2008,29(3):164-167. 被引量：4
  • 2张向鑫,李庆浩,李清.P-选择素与心肌缺血再灌注损伤[J].社区医学杂志,2004,2(3):26-28. 被引量：6
  • 3蔡丽萍,方平,谭跃萍,宋维,刘增波.靶向超声介导抗细胞间黏附因子-1单克隆抗体对大鼠心肌缺血再灌注损伤的实验性研究[J].中国超声医学杂志,2005,21(10):727-729. 被引量：2
  • 4蔡丽萍,方平,谭跃萍,宋维,刘增波.靶向超声介导VEGF_(165)cDNA基因治疗大鼠心肌缺血的实验研究[J].中华超声影像学杂志,2005,14(11):854-857. 被引量：5
  • 5Wei J, Sean RH, Michael PW, et al. Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury [J]. Am J Pathol, 2008,172(3) :592-602.
  • 6Claudine SB, Wai YS, Tyson M, et al. Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation[J]. Blood, 2009,113 (9): 2108- 2117.
  • 7Kimiyasu E,Toyoaki M, Mika A, et al. Ischemia-induced angiogenesis: role of inflammatory response mediated by P-selectin[J]. J Leukoc Biol, 2006,79 (5) :971-976.
  • 8Janine MG, Jaap JZ, Peter LH. Molecular and functional interactions among monocytes, platelets,and endothelial cells and their relevance for cardiovascular diseases[J]. J Leukoc Biol, 2009,85(2) :195- 204.
  • 9Barrabes JA, Mirabet M, Agullo L, et al. Platelet deposition in remote cardiac regions after coronary occlusion[J]. Clinical Investigation, 2007,37(12) : 939-946.
  • 10Gertie JO, Miroslava P, Ralf JL, et al. Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody-or small-molecule-mediated inhibition of selectin-dependent platelet functions [ J ]. Haematologica, 2007,92(4),502-512.

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临床超声医学杂志
2016年 第2期

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