血清Aβ1-42浓度与缺血性卒中后认知障碍的相关性研究

The correlation of serum Aβ1-42 concentration and cognitive impairment after ischemic stroke

目的探讨血清β淀粉样蛋白1-42（Aβ1-42）浓度与缺血性卒中后认知障碍的相关性。方法收集2014年12月～2015年8月在我院神经内科住院治疗的缺血性脑卒中后3个月患者110例及健康志愿者50例。收集入组者的临床资料,采用ELISA法测定血清Aβ1-42浓度,比较各组血清Aβ1-42浓度的差异,分析血清Aβ1-42浓度与缺血性卒中后认知障碍的关系。结果 1缺血性卒中后认知障碍组血清Aβ1-42浓度（94.16±39.30pg/ml）明显低于认知功能正常组（123.84±36.50）pg/ml,P〈0.001,差异有统计学意义。2多因素Logistic回归分析示血清Aβ1-42浓度OR=0.977,OR95%CI=0.963～0.992,P=0.002。结论 1缺血性卒中后认知障碍患者血清Aβ1-42浓度较正常对照组显著降低。2低血清Aβ1-42浓度是缺血性卒中后认知障碍的独立危险因素之一。

Objective To explore the correlation of serum Aβ1-42 concentration and cognitive impairment after is-chemic stroke. Methods 110 patients with ischemic stroke after 3 months and 50 cases of healthy volunteers were collected during Dec 2014 to Aug 2015 in Neurology of our hospital. Collected the clinical data of each group and the concentration of serum Aβ1-42 were determinated by ELISA. Compared the differences of serum Aβ1-42 concentration of each group, and ana-lyzed the relationship between post-ischemic stroke cognitive impairment and concentration of serum Aβ1-42. Results ①The concentration of serum Aβ1-42 of post-ischemic stroke cognitive impairment group [（94.16±39.30）pg/ml] was lower than that in normal cognitive function group [（123.84±36.50）pg/ml], P〈0.001, the difference was statistically significant. ②Multi-factor Lo-gistic regression analysis showed that serum Aβ1-42 concentration OR=0.977,OR95%CI=0.963~0.992,P=0.002. Conclu-sion ①The concentration of serum Aβ1-42 of post-ischemic stroke cognitive impairment group is lower than that in normal cognitive function group. ②Low serum Aβ1-42 concentration is an independent risk factor for post-ischemic stroke cognitive impairment.