卵巢低氧微环境调节哺乳动物排卵的分子机制

A mechanistic review of how hypoxic mircroenvironment regulates mammalian ovulation

哺乳动物排卵过程复杂,包括卵泡发育、卵泡成熟破裂后的排卵以及黄体形成和退化等过程。目前研究表明,排卵过程受低氧微环境和响应低氧条件的因子—低氧诱导因子(Hypoxic inducible factor,HIF)的影响。低氧调控HIF并影响许多生理过程,如血管生成、炎症反应等。尽管排卵的具体过程早已阐明,但低氧参与调控排卵过程的分子机制并不十分清楚。本文主要综述了哺乳动物在排卵过程中低氧环境如何产生以及HIF如何调控该过程的分子机制,旨在进一步理解排卵机制和卵巢的综合性功能,为相关的卵巢疾病提供一定的理论依据。

Mammalian ovulation is a complicated process that includes development of follicles, ovulation, for- mation of corpus luteum and luteolysis. The three different stages of the ovulation activity are affected by hypoxic microenvironment and hypoxia-induced factors （HIF）, which play a crucial role in physiologyical processes, such as angiogenesis and inflammation. Although the process of ovulation has been well elucidated, the molecular mechanism regulated by hypoxia needs an in depth study. In this review, we summarize how hypoxic and HIF regulate gene ex- pression during mammalian ovulation in order to provide a better understanding of ovulation mechanism, which may lay a theoretical basis for prevention and therapy of various ovarian diseases.