58株致肺炎金黄色葡萄球菌耐药性分布及耐药菌体外诱导耐药情况分析

Drug Resistance Distribution of 58 Strains of Staphylococcus Aureus Leading to Pneumonia and Situation Analysis of Drug-fast Bacteria in Vitro Induction of Resistance

目的以58株金黄色葡萄球菌为例,分析其耐药性分布,指导临床抗生素的合理使用。通过体外诱导耐药,初步探讨其耐药机制。方法整群选取该院2013年3月—2014年3月临床分离得到的58株金黄色葡萄球菌,进行药敏实验,分析其耐药性分布。通过体外诱导法建立金黄色葡萄球菌的耐药模型,初步探讨其耐药机制。结果 58株金黄色葡萄球菌中,分离出32株耐甲氧西林金黄色葡萄球菌(MRSA),占金黄色葡萄球菌的55.2%。金黄色葡萄球菌主要分布在ICU病房、呼吸内科以及神经外科。主要感染标本为痰液和分泌物。所分离到的58株菌对万古霉素和利奈唑胺均敏感,青霉素耐药率为98.3%。结论金黄色葡萄球菌主要分布在门诊、ICU等科室,且耐药菌株的数量已不容乐观,应引起临床上的足够重视,加强抗生素合理使用的管理以及对金黄色葡萄球菌感染的监测。

Objective To analyze the drug resistance distribution by taking 58 strains of staphylococcus aureus for example in order to guide the rational use of clinical antibiotics and preliminarily discuss the drug resistance mechanism by in vitro induction of resistance. Methods 58 strains of Staphylococcus aureus obtained by clinical isolates from March 2013 to March 2014 were selected and the drug resistance distribution of them were analyzed by drug sensitivity test, the drug re-sistance model of staphylococcus aureus was built by in vitro induction method and its drug resistance mechanism was pre-liminarily discussed. Results 32 strains of staphylococcus aureus （MRSA） were separated from 58 strains of staphylococcus aureus, accounting for 55.2% of staphylococcus aureus, staphylococcus aureus was mainly distributed in the ICU ward, res-piratory department of internal medicine and department of neurosurgery, the main infection specimens were sputum and se-cretion, the isolated 58 strains were sensitive to vancomycin and linezolid, the drug resistance rate of penicillin was 98.3%. Conclusion Staphylococcus aureus is mainly distributed in the clinic, ICU and other departments and the number of resis-tant strains is not optimistic, and we should pay enough attention to it in clinic by strengthening the management of antibi-otics and monitoring of staphylococcus aureus infection.