玻璃酸钠治疗中度膝关节骨性关节炎远期分析

Analysis of the Long-term Effect of Sodium Hyaluronate in the Treatment of Moderate Knee Osteoarthritis

目的研究膝关节骨性关节炎患者在临床治疗中,应用玻璃酸钠的效果。方法整群选取该院2011年1月—2014年12月收治的膝关节骨性关节炎患者82例作为研究对象,随机分为两个不同组别。其中一组采用常规药物治疗,另一组加用玻璃酸钠注射治疗。观察两组患者的临床治疗效果,比较膝关节功能和生活质量状况。结果试验组患者治疗优良共计36例(87.8%),对照组治疗优良28例(68.3%),两组差异有统计学意义。1年随访结果显示,试验组患者膝关节行走能力、上下楼能力、屈曲程度、肿胀程度、综合能力评分优于对照组,躯体功能、心理功能、社会功能评分高于对照组。差异有统计学意义(P<0.05)。结论膝关节骨性关节炎患者采用玻璃酸钠注射治疗效果确切,能够提高治疗优良率,促进膝关节功能恢复,改善生活质量,具有良好的远期疗效。

Objective To study the effect of sodium hyaluronate in the treatment of patients with knee osteoarthritis. Meth-ods 82 cases of knee osteoarthritis admitted in our hospital from January 2011 to December 2014 were selected as the sub-jects and randomly divided into two groups. One group was treated with conventional drugs, and the other was treated with sodium hyaluronate injection combined with conventional drugs. The clinical therapeutic effect of the two groups was ob-served. And the knee joint function and quality of life of the two groups were compared. Results In the experimental group, the treatment effect was excellent and good in 36 cases （87.8%）, while in the control group, that was excellent and good in 28 cases （68.3%）, the difference between the two groups was statistically significant. One year follow-up results showed that the knee joint walking ability, downstairs ability, buckling degree, degree of swelling and comprehensive ability scores of the experimental group were better than those of the control group, physical function, psychological function, social function scores of the experimental group were higher than those of the control group with statistical significant difference, P〈0.05. Conclusion For patients with osteoarthritis of the knee, sodium hyaluronate injection has exact effect, which can improve the excellent and good rate of treatment, promote the recovery of knee joint function, and improve the quality of life with good long-term effect.