81例胃溃疡伴胆汁反流患者临床疗效分析

Clinical Efficacy Analysis of Patients with Gastric Ulcer with Bile Reflux

目的通过对临床患者不同治疗方法的对比研究,探讨胃溃疡伴胆汁反流患者的有效治疗方案。方法整群2012年3月—2015年3月入该院治疗的162例胃溃疡伴胆汁反流患者,随机平均分为治疗组81例,对照组81例。对照组采用奥美拉唑常规治疗,治疗组采用奥美拉唑联合铝碳酸镁治疗[1]。观察2组临床疗效及胃镜下溃疡恢复情况。结果临床症状总有效率93.8%,对照组66.7%;胃镜下观察临床疗效,治疗组总有效率92.6%,对照组67.9%。统计学比较,差异有统计学意义(P<0.05)。治疗后,患者无明显不适症状,肝肾功能检查结果均在正常值,未见明显药物不良反应。结论奥美拉唑联合铝碳酸镁治疗胃溃疡伴胆汁反流较单纯应用奥美拉唑治疗有效率更高,能够有效缓解反流症状,并促进溃疡愈合,有临床治疗意义,适合临床广泛推广。

Objective To explore the effective treatment for patients with gastric ulcer with bile reflux though the compara-tive study of different treatment methods for clinical patients. Methods patients with gastric ulcer with bile reflux treated in our hospital from March 2012 to March2015was randomly divided into the treatment group and the control group, each group has 81 cases. The control group were treated with omeprazole while the treatment group were treated with Omeprazole combined with hydrotalcite,and the clinical effect and endoscopic ulcer recovery of the two groups was observed.Results The total effective rate of clinical symptoms was 93.8%and the control group was 66.7%;the total effective rate of the clini-cal curative effect under gastroscopy in the treatment group was 92.6%and 67.9% in the control group, which were statisti-cally significant （P〈0.05）.patients had no obvious symptoms after treatment and theirliver and kidney function test results were normal, there were no obvious adverse drug reactions. Conclusion The efficiency of omeprazole combined withhydro-talcite in treatment of patients with gastric ulcer with bile reflux was higher than simple application of omeprazole,which can effectively alleviate the symptoms of reflux and promote ulcer healing, so it was of great clinical treatment significance and was suitable for clinical extensive promotion.