硝唑尼特对大黄鱼幼鱼的急性毒性试验

Acute toxicity tests of nitazoxanide on fingerings of large yellow croaker

在水温25~27℃、p H值8.1~8.2条件下,将硝唑尼特溶解于二甲亚砜制成溶液,采用静水试验法研究硝唑尼特对大黄鱼幼鱼的急性毒性。试验结果表明：硝唑尼特对大黄鱼幼鱼24 h、48 h、72 h和96 h的半致死浓度（LC50）分别为6.69 mg/L、6.45 mg/L、5.64 mg/L和5.04mg/L;安全浓度为1.69 mg/L。硝唑尼特属高毒化学物质,但一般1 mg/L浸浴72 h即可有效驱除滋养体。因此,驱虫的有效浓度属安全浓度范围,在生产中使用是安全的。

Under the conditions of water temperature of 25 -27012 and pH of 8.1 -8.2, compounding the solution by nita- zoxanide dissolved in dimethyl sulfoxide and using the hydrostatic test method, the acute toxicity of nitazoxanide on fingerings of large yellow croaker were studied. The test results showed that 24 h,48 h, 72 h and 96 h median lethal concentration （LC50） of nitazoxanide on fingerings of large yellow croaker was 6.69 mg/L, 6.45 rag/L, 5.64 mg/L and 5.04 mg/L respectively, and safe concentration was 1.69 mg/L. Nitazoxanide belongs to high toxic chemicals, but generally that of 1 mg/L in the 72 - hour immersion bath can effectively remove trophozoite, therefore, the effective concentrations of insect repellent is within the range of the safe concentration and it is safe to use in production.