氯吡格雷辅助治疗进行性脑梗死的可行性及对CSS评分的影响

Feasibility of clopidogrel in adjuvant therapy of progressive cerebral infarction and effect on CSS score

目的探究使用氯吡格雷辅助阿司匹林治疗进行性脑梗死的临床效果,评估其临床推广可行性。方法选取进行性脑梗死患者98例,随机分为观察组和对照组。在常规治疗的基础上,对照组患者口服阿司匹林,观察组患者在对照组患者治疗的基础上,口服氯吡格雷辅助治疗。两组患者均持续服药4周。对两组患者进行CSS评分,观察两组患者症状改善情况、各种服药不良反应发生情况及各项生化指标,对比评价氯吡格雷辅助阿司匹林治疗的可行性。结果观察组总有效率高于对照组(P<0.05);观察组血小板平均凝集率小于对照组,AR及ASR发生率也明显小于对照组(P<0.05);治疗周期结束后观察组患者CSS评分明显低于对照组患者(P<0.05);观察组不良反应总发生率略低于对照组(P<0.05)。结论氯吡格雷辅助阿司匹林治疗进行性脑梗死具有良好的临床效果,值得临床推广。

Objective To study the clinical effect of clopidogrel adjuvant aspirin in the treatment of progressive cerebral infarction, to evaluate the feasibility on clinical popularization. Methods 98 patients with progressive cerebral infarction were selected,and were divided into observation group and control group.Patients in control group were treated with persral aspirin bassed on routine treatment,while patients in observation group were treated with persral clopidogrel adjuvant aspirin,the two groups were all persistent taking medicine for 4 weeks.To carry out CSS score of patients in the two groups,to observe the condition of symptom improvement,the occurrence condition of adverse reactions in various taking medicine,and various biochemical indexes of patients in the two groups,to comparatively evaluate the feasibility of clopidogrel adjuvant aspirin treatment. Results The total effective rate group was higher,the average platelet aggregation rate was less,the incidence of AR and ASR was obviously less,the CSS score after completion of treatment cycle was obviously lower,the total incidence adverse reactions was slightly lower compared with observation group and control group（P〈 0.05）. Conclusion Clopidogrel adjuvant aspirin in the treatment of progressive cerebral infarction has better clinical effect, is worthy of clinical popularization.