病证结合的肠易激综合征动物模型研究进展

Disease and pattern-based Irritable Bowel Syndrome (IBS) Animal Models

本文旨在总结近几年肠易激综合征在中医药相关研究中建立的病证结合动物模型。发现相应病证结合动物模型的研究并未随着证型分布的研究而深入,仅在肝气乘脾证、肝郁气滞证、脾肾阳虚证、脾胃湿热证等证型的研究较多。本文遂从证型角度探索以上证型模型的研究进展。

In this review, we summarize experimental animal models of irritable bowel syndrome （IBS） based on differentiation of disease and pattern in traditional Chinese medicine （ TCM ） . Our findings show that the corresponding animal models involve only a few patterns, instead of covering all the patterns. Liver-qi stagnation pattern, the pattern of the liver overacting on the spleen, yang deficiency pattern of the spleen and kidney and the pattern of dampness-heat in the spleen and stomach are patterns most often studied. This review summarizes the research progress of the above models from the perspective of pattern types.